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【结 构 式】

【分子编号】62970

【品名】ethyl 7-{3-[acetyl(methyl)amino]phenyl}pyrazolo[1,5-a]pyrimidine-3-carboxylate

【CA登记号】

【 分 子 式 】C18H18N4O3

【 分 子 量 】338.36608

【元素组成】C 63.89% H 5.36% N 16.56% O 14.19%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XXVII)

Cyclization of 5-aminopyrazole-4-carboxylic acid ethyl ester (XXI) with either, 3,3-diethoxypropionic acid ethyl ester (XXII) or 3-oxopropionic acid ethyl ester (XXIII) in refluxing AcOH gives 7-hydroxypyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester (XXIV), which is treated with POCl3 to yield the corresponding chloro derivative (XXV). Condensation of compound (XXV) with 3-(N-methylacetamido)phenylboronic acid (XXVI) by means of Pd(PPh3)4 and Na2CO3 in ethanol affords the pyrazolo-[1,5-a]pyrimidine-carboxylic acid ethyl ester (XXVII), which is finally condensed with 2-bromothiophene (XX) and Mg.

1 Sorbera, L.A.; Castaner, J.; Martin, L.; Indiplon. Drugs Fut 2003, 28, 8, 739.
2 Wilcoxen, K.M.; Gross, R.S. (Neurocrine Biosciences Inc.); Synthesis of substd. pyrazolopyrimidines. WO 0110868 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XX) 13681 2-Bromothiophene 1003-09-4 C4H3BrS 详情 详情
(XXI) 51140 3-Amino-4-pyrazolecarboxylic acid ethyl ester; Ethyl 3-aminopyrazole-4-carboxylate; 3-Amino-4-carbethoxypyrazole 6994-25-8 C6H9N3O2 详情 详情
(XXII) 17901 Ethyl 3,3-diethoxypropanoate 10601-80-6 C9H18O4 详情 详情
(XXIII) 62966 ethyl 3-oxopropanoate C5H8O3 详情 详情
(XXIV) 62967 ethyl 7-hydroxypyrazolo[1,5-a]pyrimidine-3-carboxylate C9H9N3O3 详情 详情
(XXV) 62968 ethyl 7-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate C9H8ClN3O2 详情 详情
(XXVI) 62969 3-[acetyl(methyl)amino]phenylboronic acid C9H12BNO3 详情 详情
(XXVII) 62970 ethyl 7-{3-[acetyl(methyl)amino]phenyl}pyrazolo[1,5-a]pyrimidine-3-carboxylate C18H18N4O3 详情 详情
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