|
【结 构 式】 
|
【分子编号】62828 【品名】2-(2,6-dichloro-4-hydroxyphenyl)tricyclo[3.3.1.13,7]decan-2-ol 【CA登记号】 |
【 分 子 式 】C16H18Cl2O2 【 分 子 量 】313.22312 【元素组成】C 61.35% H 5.79% Cl 22.64% O 10.22% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Preparation of the intermediate aryl triflate (V) is shown is Scheme 29890101a. The dilithiated derivative of 4-bromo-3,5-dichlorophenol (I) is condensed with 2-adamantanone (II) to produce the carbinol adduct (III). Reduction of the tertiary alcohol of (III) by means of concentrated HI in boiling AcOH leads to the adamantanyl phenol (IV). This is then reacted with trifluoromethanesulfonic anhydride in cold pyridine to yield sulfonate (V).
| 【1】 Paul, R.; Boigegrain, R.; Nisato, D.; Casellas, P.; Herbert, J.M.; Bourrie, B.; Bourrie, M.; Lair, P.; Vernieres, J.C. (Sanofi-Synthélabo); Benzene derivs., preparation method and pharmaceutical compsns. containing same. EP 1192122; FR 2794742; JP 2003502306; US 6482986; WO 0076953 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 62827 | 4-bromo-3,5-dichlorophenol | C6H3BrCl2O | 详情 | 详情 | |
| (II) | 40404 | 2-adamantanone | 700-58-3 | C10H14O | 详情 | 详情 |
| (III) | 62828 | 2-(2,6-dichloro-4-hydroxyphenyl)tricyclo[3.3.1.13,7]decan-2-ol | C16H18Cl2O2 | 详情 | 详情 | |
| (IV) | 62829 | 3,5-dichloro-4-tricyclo[3.3.1.13,7]dec-2-ylphenol | C16H18Cl2O | 详情 | 详情 | |
| (V) | 62830 | 3,5-dichloro-4-tricyclo[3.3.1.1~3,7~]dec-2-ylphenyl trifluoromethanesulfonate | C17H17Cl2F3O3S | 详情 | 详情 |
Extended Information