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【结 构 式】 
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【分子编号】62805 【品名】(2R)-1-{[(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidinyl]carbonyl}-N-[(3S)piperidinylmethyl]-2-pyrrolidinecarboxamide 【CA登记号】 |
【 分 子 式 】C37H44N4O4 【 分 子 量 】608.78092 【元素组成】C 73% H 7.28% N 9.2% O 10.51% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XII)Coupling of acid (IX) with (R)-3-(aminomethyl)-1-Boc-piperidine (X) gives the triamide (XI). Deprotection of both N-Boc and O-t-butyl groups of (XI) with trifluoroacetic acid affords (XII). Finally, reductive alkylation of piperidine (XII) with propionaldehyde in the presence of NaBH3CN/ZnCl2 provides the target compound.
| 【1】 Sagara, Y.; Kimura, T.; Fujikawa, T.; Noguchi, K.; Ohtake, N.; Identification of novel muscarinic M3 selective antagonists with a conformationally restricted Hyp-Pro spacer. Bioorg Med Chem Lett 2003, 13, 1, 57. |
| 【2】 Kimura, T.; Noguchi, K.; Otake, N.; Uchiyama, M.; Naya, A.; Sagara, Y.; Numazawa, T.; Fujikawa, T. (Banyu Pharmaceutical Co., Ltd.); Novel amide derivs.. EP 1213281; WO 0107406 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IX) | 62803 | (2R)-1-{[(2S,4R)-4-(tert-butoxy)-1-(3,3,3-triphenylpropanoyl)pyrrolidinyl]carbonyl}-2-pyrrolidinecarboxylic acid | C35H40N2O5 | 详情 | 详情 | |
| (X) | 57643 | tert-butyl (3R)-3-(aminomethyl)-1-piperidinecarboxylate | C11H22N2O2 | 详情 | 详情 | |
| (XI) | 62804 | tert-butyl (3R)-3-({[((2R)-1-{[(2S,4R)-4-(tert-butoxy)-1-(3,3,3-triphenylpropanoyl)pyrrolidinyl]carbonyl}pyrrolidinyl)carbonyl]amino}methyl)-1-piperidinecarboxylate | C46H60N4O6 | 详情 | 详情 | |
| (XII) | 62805 | (2R)-1-{[(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidinyl]carbonyl}-N-[(3S)piperidinylmethyl]-2-pyrrolidinecarboxamide | C37H44N4O4 | 详情 | 详情 |
Extended Information