|
【结 构 式】 
|
【分子编号】62723 【品名】(2R)-2-(4-iodophenyl)propanoic acid 【CA登记号】 |
【 分 子 式 】C9H9IO2 【 分 子 量 】276.07373 【元素组成】C 39.16% H 3.29% I 45.97% O 11.59% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(LIV)In an asymmetric synthesis of the title compound, aldehyde (V) was oxidized with sodium chlorite to afford the corresponding racemic acid, which was resolved via formation of the diastereoisomeric salts with cinchonidine. The target (R)-2-(4-iodophenyl)propionic acid (LIV) was then converted to the zinc salt and subsequently coupled to 3-methyl-2-thienylmagnesium bromide (VIII) in the presence of palladium catalyst to provide the desired chiral arylpropionic acid
| 【1】 Arai, H.; Tanaka, K.; Watanabe, I.; Kodama, T.; Hirano, H.; Abe, N.; Nakabayashi, M. (Toyama Chemical Co., Ltd.); Novel 2-[4-(3-methyl-2-thienyl)phenyl]propionic acid and pharmaceutically acceptable salt thereof and method for treating symptoms of inflammation and pain. US 4230719 . |
Extended Information