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【结 构 式】 
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【分子编号】62562 【品名】benzyl (3S,4R,5S)-4-[(tert-butoxycarbonyl)amino]-3-hydroxy-5-methylheptanoate 【CA登记号】 |
【 分 子 式 】C20H31NO5 【 分 子 量 】365.46988 【元素组成】C 65.73% H 8.55% N 3.83% O 21.89% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(LV)A modification of the previous synthetic methods was further reported. The protected isostatine (XI) was prepared by a related procedure utilizing benzyl ester protected intermediates instead of the methyl ester analogues. After activation of N-Boc-D-allo-isoleucine (VII) with carbonyl diimidazole, condensation with the lithium enolate of benzyl acetate yielded keto ester (LIV). Reduction of the keto group of (LIV), followed by silylation of the resultant alcohol (LV) and benzyl group hydrogenolysis led to the amino hydroxy acid derivative (XI)
| 【1】 Edge, A. (Diacrin, Inc.); Method for improving graft acceptance in a recipient by administration of a cytokine profile altering agent. WO 0051630 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VII) | 50775 | (2R,3S)-2-[(tert-butoxycarbonyl)amino]-3-methylpentanoic acid | C11H21NO4 | 详情 | 详情 | |
| (XI) | 50802 | (3S,4R,5S)-4-[(tert-butoxycarbonyl)amino]-3-[[tert-butyl(dimethyl)silyl]oxy]-5-methylheptanoic acid | C19H39NO5Si | 详情 | 详情 | |
| (LIV) | 62561 | benzyl (4R,5S)-4-[(tert-butoxycarbonyl)amino]-5-methyl-3-oxoheptanoate | C20H29NO5 | 详情 | 详情 | |
| (LV) | 62562 | benzyl (3S,4R,5S)-4-[(tert-butoxycarbonyl)amino]-3-hydroxy-5-methylheptanoate | C20H31NO5 | 详情 | 详情 |
Extended Information