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【结 构 式】 
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【分子编号】62560 【品名】 【CA登记号】 |
【 分 子 式 】C60H100N6O14Si 【 分 子 量 】1157.57154 【元素组成】C 62.26% H 8.71% N 7.26% O 19.35% Si 2.43% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XXVIII)Sequential deprotection of the trichloroethyl ester and the N-benzyloxycarbonyl groups of (LI) led to (LII) and the linear aminoacid (LIII), which underwent macrocyclization to the N-Boc didemnin A (XXVIII) upon treatment with HATU and HOAt. The title compound was then obtained by acidic Boc group deprotection, followed by coupling with pyruvyl proline as outlined in Schemes 23437701e and 23437701f
| 【1】 Jou, G.; Gonzalez, I.; Albericio, F.; Lloyd-Williams, P.; Giralt, E.; Total synthesis of dehydrodidemnin B. Use of uronium and phosphonium salt coupling reagents in peptide synthesis in solution. J Org Chem 1997, 62, 2, 354. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XXVIII) | 62560 | C60H100N6O14Si | 详情 | 详情 | ||
| (LI) | 62557 | 2,2,2-trichloroethyl (2S)-1-{(2S,7S,11S,12R,15S,16R,19S)-15-({(2R)-2-[(tert-butoxycarbonyl)(methyl)amino]-4-methylpentanoyl}amino)-11-{[tert-butyl(dimethyl)silyl]oxy}-2-isobutyl-7-isopropyl-19-(4-methoxybenzyl)-5,16,20-trimethyl-12-[(1S)-1-methylpro | C70H109Cl3N6O17Si | 详情 | 详情 | |
| (LII) | 62558 | (2S)-1-{(2S,7S,11S,12R,15S,16R,19S)-15-({(2R)-2-[(tert-butoxycarbonyl)(methyl)amino]-4-methylpentanoyl}amino)-11-{[tert-butyl(dimethyl)silyl]oxy}-2-isobutyl-7-isopropyl-19-(4-methoxybenzyl)-5,16,20-trimethyl-12-[(1S)-1-methylpropyl]-4,6,9,14,18,21-h | C68H108N6O17Si | 详情 | 详情 | |
| (LIII) | 62559 | (2S)-1-{(2S,7S,11S,12R,15S,18R)-11-{[tert-butyl(dimethyl)silyl]oxy}-2,18-diisobutyl-7-isopropyl-15-((1R)-1-{[(2S)-3-(4-methoxyphenyl)-2-(methylamino)propanoyl]oxy}ethyl)-5,19,22,22-tetramethyl-12-[(1S)-1-methylpropyl]-4,6,9,14,17,20-hexaoxo-8,21-dio | C60H102N6O15Si | 详情 | 详情 |
Extended Information