(2S)-1-[4-(benzyloxy)phenyl]-2-(4-hydroxy-4-phenyl-1-piperidinyl)-1-propanone -Drug Synthesis Database

【结构式】

【分子编号】62512

【品名】(2S)-1-[4-(benzyloxy)phenyl]-2-(4-hydroxy-4-phenyl-1-piperidinyl)-1-propanone

【CA登记号】

【分子式】C₂₇H₂₉NO₃

【分子量】415.5322

【元素组成】C 78.04% H 7.03% N 3.37% O 11.55%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VIIII)

In a related process, the racemic piperidinyl ketone (VII) was initially resolved employing D-tartaric acid. The target (2S)-piperidinyl propanone (VIII) was then diastereoselectively reduced to the (1S,2S)-alcohol (IX) employing LiBH4 in EtOH. Finally, debenzylation of (IX) by catalytic hydrogenolysis yielded the title compound

参考文献中间体

合成目标

【1】 Walinsky, S.W.; Rainville, J.P.; Sinay, T.G. Jr. (Pfizer Products Inc.); Process for the preparation of the mesylate salt trihydrate of 1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol and intermediates useful therefor. EP 1149831 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(VIIII)	62512	(2S)-1-[4-(benzyloxy)phenyl]-2-(4-hydroxy-4-phenyl-1-piperidinyl)-1-propanone	C₂₇H₂₉NO₃	详情	详情
(VII)	62510	1-[4-(benzyloxy)phenyl]-2-(4-hydroxy-4-phenyl-1-piperidinyl)-1-propanone	C₂₇H₂₉NO₃	详情	详情
(IX)	62511	1-{(1S,2S)-2-[4-(benzyloxy)phenyl]-2-hydroxy-1-methylethyl}-4-phenyl-4-piperidinol	C₂₇H₃₁NO₃	详情	详情

Extended Information