9H-dinaphtho[2,1-g:1,2-i][1,5]dioxacycloundecine-7,10,13(11H)-trione -Drug Synthesis Database

【结构式】

【分子编号】62437

【品名】9H-dinaphtho[2,1-g:1,2-i][1,5]dioxacycloundecine-7,10,13(11H)-trione

【CA登记号】

【分子式】C₂₅H₁₆O₅

【分子量】396.39904

【元素组成】C 75.75% H 4.07% O 20.18%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IX)

A different method for the preparation of glycidic ester (VI) consists in the asymmetric epoxidation of ethyl 4-methoxycinnamate (I) with oxone(R) in the presence of chiral macrocyclic ketones, such as the binaphthyl ketone (IX)

参考文献中间体

合成目标

【1】 Seki, M.; Furutani, T.; Imashiro, R.; Kuroda, T.; Yamanaka, T.; Harada, N.; Arawaka, H.; Kusama, M.; Hashiyama, T.; A novel synthesis of a key intermediate for diltiazem. Tetrahedron Lett 2001, 42, 46, 8201.
【2】 Ozaki, Y.; Arakawa, H.; Harada, N.; Hashiyama, T.; Kuroda, T.; Seki, M.; Kusama, M. (Tanabe Seiyaku Co., Ltd.); Process for preparing optically active phenyloxirane cpds.. WO 9856762 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	62431	ethyl (E)-3-(4-methoxyphenyl)-2-propenoate	C₁₂H₁₄O₃	详情	详情
(VI)	62435	ethyl (2R,3S)-3-(4-methoxyphenyl)-2-oxiranecarboxylate	C₁₂H₁₄O₄	详情	详情
(IX)	62437	9H-dinaphtho[2,1-g:1,2-i][1,5]dioxacycloundecine-7,10,13(11H)-trione	C₂₅H₁₆O₅	详情	详情

Extended Information