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【结 构 式】

【分子编号】62410

【品名】 

【CA登记号】

【 分 子 式 】C10H16ClN

【 分 子 量 】185.69648

【元素组成】C 64.68% H 8.68% Cl 19.09% N 7.54%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XXIV)

The key intermediate (XXI) was also prepared by several related procedures. Chlorination of aminoalcohol (XVI) gave chloro amine (XXIV), which was condensed with 2-aminobenzyl alcohol (X) to afford diamine (XXV). Then, alkylation of diamine (XXV) with dibromoethane (XIII) in hot pyridine gave rise to the target piperazine (XXI). Alternatively, diamine (XXV) was condensed with ethyl chloroacetate or with diethyl oxalate to produce the mono- or dioxopiperazines (XXVII) and (XXVI), respectively, which were then reduced to (XXI) by means of LiAlH4. Cyclization of alcohol (XXI) to the title compound was achieved by treatment with concentrated sulfuric acid

1 Olivié, J.; Synthesis for the preparation of tetracyclic cpds.. US 4217452 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
16601 ethyl chloroacetate; ethyl 2-chloroacetate 105-39-5 C4H7ClO2 详情 详情
(X) 18619 (2-aminophenyl)methanol; 2-Amino-benzenemethanol;2-Hydroxymethyl aniline;2-aminobenzyl alcohol;o-Aminobenzyl 2-aminobenzylalcohol;alcohol; 2-aminobenzenemethanol; 2-aminobenzyl alcohol 5344-90-1 C7H9NO 详情 详情
(XIII) 10252 1,2-Dibromoethane; Ethylene dibromide 106-93-4 C2H4Br2 详情 详情
(XVI) 62404 2-(methylamino)-1-phenyl-1-ethanol C9H13NO 详情 详情
(XXI) 62407 [2-(4-methyl-2-phenyl-1-piperazinyl)phenyl]methanol C18H22N2O 详情 详情
(XXIV) 62410   C10H16ClN 详情 详情
(XXV) 62411 (2-{[2-(methylamino)-1-phenylethyl]amino}phenyl)methanol C16H20N2O 详情 详情
(XXVI) 62413 4-[2-(hydroxymethyl)phenyl]-1-methyl-5-phenyl-2,3-piperazinedione C18H18N2O3 详情 详情
(XXVII) 62412 1-[2-(hydroxymethyl)phenyl]-4-methyl-6-phenyl-2-piperazinone C18H20N2O2 详情 详情
Extended Information