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【结 构 式】

【分子编号】62362

【品名】2-(acetyloxy)ethyl acetate

【CA登记号】

【 分 子 式 】C6H10O4

【 分 子 量 】146.143

【元素组成】C 49.31% H 6.9% O 43.79%

与该中间体有关的原料药合成路线共 2 条

合成路线1

该中间体在本合成路线中的序号:(II)

In a related procedure, 1-(acetoxymethyl)-2-methyl-4-nitroimidazole (I) is condensed with ethyleneglycol diacetate (II) in the presence of anhydrous H2SO4, followed by hydrolysis or alcoholysis under acidic conditions to produce the title compound

1 Buforn, A.; Massonneau, V.; Mulhauser, M. (Aventis SA); Process for the preparation of 1-hydroxyalkyl-2-methyl-5-nitro-imidazoles. EP 0325513; FR 2625999 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 62361 (2-methyl-4-nitro-1H-imidazol-1-yl)methyl acetate C7H9N3O4 详情 详情
(II) 62362 2-(acetyloxy)ethyl acetate C6H10O4 详情 详情

合成路线2

该中间体在本合成路线中的序号:(IV)

The title compound can also be obtained by alkylation, in different solvents, of 1-(acetoxymethyl)-2-methyl-4-nitroimidazole (I) with either ethylene sulfate (II) or with bis-(2-acetoxyethyl) sulfate (III) -generated from ethyleneglycol diacetate (IV) and either dimethyl sulfate or H2SO4 - followed by hydrolysis or alcoholysis treatment

1 Massonneau, V.; Mulhauser, M.; Buforn, A. (Aventis Pharma SA); Process for the preparation of hydroxyalkylating agents, the agents so prepared and their use. EP 0324692 .
2 Massonneau, V.; Mulhauser, M.; Buforn, A.; Madard-Cazin, B. (Aventis Pharma SA); Process for the preparation of 1-hydroxyalkyl-5-nitro-imidazoles. EP 0324691 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 62361 (2-methyl-4-nitro-1H-imidazol-1-yl)methyl acetate C7H9N3O4 详情 详情
(II) 62364 1,3,2lambda~6~-dioxathiolane-2,2-dione C2H4O4S 详情 详情
(III) 62363 4,4,9-trioxo-3,5,8-trioxa-4lambda~6~-thiadec-1-yl acetate C8H14O8S 详情 详情
(IV) 62362 2-(acetyloxy)ethyl acetate C6H10O4 详情 详情
Extended Information