ethyl [(5-phenyl-1,2,4-thiadiazol-3-yl)amino]carbothioylcarbamate -Drug Synthesis Database

【结构式】

【分子编号】62359

【品名】ethyl [(5-phenyl-1,2,4-thiadiazol-3-yl)amino]carbothioylcarbamate

【CA登记号】

【分子式】C₁₂H₁₂N₄O₂S₂

【分子量】308.38504

【元素组成】C 46.74% H 3.92% N 18.17% O 10.38% S 20.8%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

In a similar method, 3-amino-5-phenyl-1,2,4-tiadiazole (I) is coupled with ethoxycarbonyl isothiocyanate to give the N-(ethoxycarbonyl)thiourea (II), which is then hydrolyzed to the title compound under alkaline conditions

参考文献中间体

合成目标

【1】 Kurzer, F.; Secker, J.L.; Addition-cyclisations of ethoxycarbonyl isothiocyanate with hydrazine derivatives as a source of thiadiazoles and triazoles. J Heterocycl Chem 1989, 26, 2, 355.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	62357	5-phenyl-1,2,4-thiadiazol-3-amine; 5-phenyl-1,2,4-thiadiazol-3-ylamine		C₈H₇N₃S	详情	详情
(II)	62359	ethyl [(5-phenyl-1,2,4-thiadiazol-3-yl)amino]carbothioylcarbamate		C₁₂H₁₂N₄O₂S₂	详情	详情

Extended Information