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【结 构 式】 
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【分子编号】62358 【品名】N-benzoyl-N'-(5-phenyl-1,2,4-thiadiazol-3-yl)thiourea 【CA登记号】 |
【 分 子 式 】C16H12N4OS2 【 分 子 量 】340.42964 【元素组成】C 56.45% H 3.55% N 16.46% O 4.7% S 18.84% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)Condensation of benzoyl chloride (I) with ammonium thiocyanate in boiling acetone produces benzoyl isothiocyanate (II). This is then coupled with the known 3-amino-5-phenyl-1,2,4-thiadiazole (III) to afford the N-benzoyl thiourea (IV) (1). Finally, hydrolysis of (IV) under alkaline conditions gives rise to the target thiadiazolyl thiourea
| 【1】 Kurzer, F.; 1,2,4-Thiadiazolylureas. A postcript to the oxidative cyclisation of thionoamidines. J Chem Soc - Perkins Trans I 1985, 2, 311. |
| 【2】 Camden, J.B. (The Procter & Gamble Co.); Thiadiazolyl urea or thiourea derivs. for antiviral treatment. JP 2002540156; US 6258831; WO 0057878 . |
| 【3】 Agyin, J.K. (The Procter & Gamble Co.); Process for the preparation of 1,2,4-thiadiazoles. US 6297384 . |
| 【4】 Camden, J.B. (The Procter & Gamble Co.); Viral treatment. JP 2002540150; US 6245788; WO 0057869 . |
| 【5】 Camden, J.B. (The Procter & Gamble Co.); Viral treatment. US 6340696 . |
Extended Information