2-(1,4-dioxaspiro[4.5]dec-2-ylmethyl)-1H-isoindole-1,3(2H)-dione -Drug Synthesis Database

【结构式】

【分子编号】62350

【品名】2-(1,4-dioxaspiro[4.5]dec-2-ylmethyl)-1H-isoindole-1,3(2H)-dione

【CA登记号】

【分子式】C₁₇H₁₉NO₄

【分子量】301.3422

【元素组成】C 67.76% H 6.36% N 4.65% O 21.24%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The condensation of 2-(chloromethyl)-1,4-dioxaspiro[4,5]decane (I) with the sodium salt of phthalimide (II) in hot DMF affords the N-substituted phthalimide (III). Subsequent phthaloyl group hydrazinolysis gives the primary amine (IV). Finally, condensation of amine (IV) with S-methyl pseudothiourea sulfate (V) leads to the title guanidine derivative

参考文献中间体

合成目标

【1】 Aaron, J.E. Jr.; Hardie, W.R.; Process for the preparation of 1,3-dioxolan-4-yl-alcoyl-guanidines and its intermediates. FR 1522153 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	62349	2-(chloromethyl)-1,4-dioxaspiro[4.5]decane		C₉H₁₅ClO₂	详情	详情
(II)	12376	Phthalimide; 1H-Isoindole-1,3(2H)-dione; Isoindole-1,3-dione;Phthalic dicarboximide;Phenylimide;Isoindole-1,3-dione	85-41-6	C₈H₅NO₂	详情	详情
(III)	62350	2-(1,4-dioxaspiro[4.5]dec-2-ylmethyl)-1H-isoindole-1,3(2H)-dione		C₁₇H₁₉NO₄	详情	详情
(IV)	62351	1,4-dioxaspiro[4.5]dec-2-ylmethanamine; 1,4-dioxaspiro[4.5]dec-2-ylmethylamine		C₉H₁₇NO₂	详情	详情
(V)	10272	[[Amino(imino)methyl]sulfanyl]methane	2986-19-8	C₂H₆N₂S	详情	详情

Extended Information