N-[5-(methylamino)-4-oxo-1,4,5,6-tetrahydro-2-pyrimidinyl]urea -Drug Synthesis Database

【结构式】

【分子编号】62276

【品名】N-[5-(methylamino)-4-oxo-1,4,5,6-tetrahydro-2-pyrimidinyl]urea

【CA登记号】

【分子式】C₆H₁₁N₅O₂

【分子量】185.18584

【元素组成】C 38.92% H 5.99% N 37.82% O 17.28%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(X)

Acid (IX) is coupled with the amino pyrimidinone derivative (X) using HATU to produce amide (XI). Finally, hydrogenolysis of the carbobenzoxy groups of (XI) in the presence of PdCl2 gives rise to the title compound

参考文献中间体

合成目标

【1】 Brands, M.; Endermann, R.; Gahlmann, R.; et al.; Novel antibiotics for the treatment of gram-positive bacterial infections. J Med Chem 2002, 45, 19, 4246.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(IX)	62275	(3S)-3-{[(benzyloxy)carbonyl]amino}-6-[({[(benzyloxy)carbonyl]amino}{[(benzyloxy)carbonyl]imino}methyl)(methyl)amino]hexanoic acid	C₃₂H₃₆N₄O₈	详情	详情
(X)	62276	N-[5-(methylamino)-4-oxo-1,4,5,6-tetrahydro-2-pyrimidinyl]urea	C₆H₁₁N₅O₂	详情	详情
(XI)	62277	benzyl (E)-[((4S)-6-[{2-[(aminocarbonyl)amino]-4-oxo-1,4,5,6-tetrahydro-5-pyrimidinyl}(methyl)amino]-4-{[(benzyloxy)carbonyl]amino}-6-oxohexyl)(methyl)amino]{[(benzyloxy)carbonyl]amino}methylidenecarbamate	C₃₈H₄₅N₉O₉	详情	详情

Extended Information