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【结 构 式】 
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【分子编号】62157 【品名】(Z,4S)-4-{[tert-butyl(diphenyl)silyl]oxy}-2-pentenoic acid 【CA登记号】 |
【 分 子 式 】C21H26O3Si 【 分 子 量 】354.52114 【元素组成】C 71.15% H 7.39% O 13.54% Si 7.92% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XX)Horner-Emmons condensation of aldehyde (XVII) with phosphonate (XVIII) gives rise to the Z-olefin (XIX). After ester group hydrolysis, the resultant carboxylic acid (XX) is coupled to amine (XVI) by using HBTU to produce amide (XXI).
| 【1】 Horigome, M.; Motoyoshi, H.; Watanabe, H.; Kitahara, T.; A synthesis of FR901464. Tetrahedron Lett 2001, 42, 46, 8207. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XVI) | 62153 | (2R,3R,5S,6S)-2,5-dimethyl-6-{(E)-3-methyl-4-[(4-methylphenyl)sulfonyl]-2-butenyl}tetrahydro-2H-pyran-3-amine; (2R,3R,5S,6S)-2,5-dimethyl-6-{(E)-3-methyl-4-[(4-methylphenyl)sulfonyl]-2-butenyl}tetrahydro-2H-pyran-3-ylamine | C19H29NO3S | 详情 | 详情 | |
| (XVII) | 62154 | (2S)-2-{[tert-butyl(diphenyl)silyl]oxy}propanal | C19H24O2Si | 详情 | 详情 | |
| (XVIII) | 62155 | ethyl 2-[bis(2,2,2-trifluoroethoxy)phosphoryl]acetate | C8H11F6O5P | 详情 | 详情 | |
| (XIX) | 62156 | ethyl (Z,4S)-4-{[tert-butyl(diphenyl)silyl]oxy}-2-pentenoate | C23H30O3Si | 详情 | 详情 | |
| (XX) | 62157 | (Z,4S)-4-{[tert-butyl(diphenyl)silyl]oxy}-2-pentenoic acid | C21H26O3Si | 详情 | 详情 | |
| (XXI) | 62158 | (Z,4S)-4-{[tert-butyl(diphenyl)silyl]oxy}-N-((2R,3R,5S,6S)-2,5-dimethyl-6-{(E)-3-methyl-4-[(4-methylphenyl)sulfonyl]-2-butenyl}tetrahydro-2H-pyran-3-yl)-2-pentenamide | C40H53NO5SSi | 详情 | 详情 |
Extended Information