N-methyl(1,2,7-trimethyl-1H-indol-3-yl)methanamine; N-methyl-N-[(1,2,7-trimethyl-1H-indol-3-yl)methyl]amine -Drug Synthesis Database

【结构式】

【分子编号】62090

【品名】N-methyl(1,2,7-trimethyl-1H-indol-3-yl)methanamine; N-methyl-N-[(1,2,7-trimethyl-1H-indol-3-yl)methyl]amine

【CA登记号】

【分子式】C₁₃H₁₈N₂

【分子量】202.2994

【元素组成】C 77.18% H 8.97% N 13.85%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VII)

N-Methyl-(1,2,7-trimethylindol-3-ylmethyl)amine (VII) is condensed with acryloyl chloride (VIII) to form the corresponding acrylamide (IX). Then, Heck coupling between acrylamide (IX) and bromonaphthyridine (VI) in the presence of palladium acetate and tri-o-tolyl phosphine gives rise to the title compound.

参考文献中间体

合成目标

【1】 Uzinskas, I.N.; Miller, W.H.; Newlander, K.A.; Jakas, D.R.; Seefeld, M.A.; DeWolf, W.E. Jr. (GlaxoSmithKline Inc.); Fab I inhibitors. EP 1226138; WO 0127103 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(VI)	56116	6-bromo-3,4-dihydro[1,8]naphthyridin-2(1H)-one		C₈H₇BrN₂O	详情	详情
(VII)	62090	N-methyl(1,2,7-trimethyl-1H-indol-3-yl)methanamine; N-methyl-N-[(1,2,7-trimethyl-1H-indol-3-yl)methyl]amine		C₁₃H₁₈N₂	详情	详情
(VIII)	11577	Acryloyl chloride; Acrylyl chloride;2-Propenoyl chloride	814-68-6	C₃H₃ClO	详情	详情
(IX)	62091	N-methyl-N-[(1,2,7-trimethyl-1H-indol-3-yl)methyl]acrylamide		C₁₆H₂₀N₂O	详情	详情

Extended Information