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【结 构 式】 
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【分子编号】62072 【品名】1,2,3,6-tetrahydro-4-pyridinecarboxylic acid 【CA登记号】 |
【 分 子 式 】C6H9NO2 【 分 子 量 】127.143 【元素组成】C 56.68% H 7.13% N 11.02% O 25.17% |
合成路线1
该中间体在本合成路线中的序号：(III)The preparation of the intermediate 1,2,3,6-tetrahydropyridine-4-carboxamide (VI) is illustrated in Scheme 1. Demethylation of tetrahydropyridine (I) with ethyl chloroformate in refluxing benzene affords carbamate (II), which is further hydrolyzed to the aminoacid (III) upon heating with concentrated HBr. Subsequent protection of (III) by means of di-t-butyl dicarbonate leads to N-Boc tetrahydropyridine-4-carboxylic acid (IV). Coupling of acid (IV) with ammonia in the presence of EDC/HOBt provides amide (V). The N-Boc protecting group of (V) is then removed with trifluoroacetic acid in CHCl3, yielding tetrahydropyridine (VI)
| 【1】 Tomisawa, K.; Kumagai, T.; Nakazato, A.; Okubo, T. (Taisho Pharmaceutical Co., Ltd.); Carbamoyl tetrahydropyridine derivs.. EP 1176146 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 43676 | methyl 10-[(hydroxyamino)carbonyl]-1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate | C10H16N2O6 | 详情 | 详情 | |
| (II) | 43674 | diethyl 3,6-dihydro-1,4(2H)-pyridinedicarboxylate | C11H17NO4 | 详情 | 详情 | |
| (III) | 62072 | 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid | C6H9NO2 | 详情 | 详情 | |
| (IV) | 62073 | 1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydro-4-pyridinecarboxylic acid | C11H17NO4 | 详情 | 详情 | |
| (V) | 62074 | tert-butyl 4-(aminocarbonyl)-3,6-dihydro-1(2H)-pyridinecarboxylate | C11H18N2O3 | 详情 | 详情 | |
| (VI) | 60299 | 1,2,3,6-tetrahydro-4-pyridinecarboxamide | C6H10N2O | 详情 | 详情 |