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【结 构 式】

【分子编号】62059

【品名】benzyl 3-aminopropylcarbamate

【CA登记号】

【 分 子 式 】C11H16N2O2

【 分 子 量 】208.26032

【元素组成】C 63.44% H 7.74% N 13.45% O 15.36%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

1,3-Diaminopropane (I) is mono-protected with benzyl chloroformate, producing carbamate (II). Coupling of (II) with N,N'-bis-Boc-S-methylisothiourea (III) yields the Boc-protected guanidine (IV). The benzyloxycarbonyl group of (IV) is then removed by catalytic hydrogenolysis to furnish the noragmatine derivative (V)

1 Szelke, M.; Evans, D.M.; Jones, D.M. (Ferring AB); Kininogen inhibitors. WO 9507291 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 19331 3-aminopropylamine; 1,3-propanediamine 109-76-2 C3H10N2 详情 详情
(II) 62059 benzyl 3-aminopropylcarbamate C11H16N2O2 详情 详情
(III) 22345 tert-butyl (E)-[(tert-butoxycarbonyl)amino](methylsulfanyl)methylidenecarbamate C12H22N2O4S 详情 详情
(IV) 62060 benzyl 3-({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)propylcarbamate C22H34N4O6 详情 详情
(V) 26836 tert-butyl (Z)-[(3-aminopropyl)amino][(tert-butoxycarbonyl)amino]methylidenecarbamate C14H28N4O4 详情 详情
Extended Information