|
【结 构 式】 
|
【分子编号】61998 【品名】5-bromo-N-(4-chloro-5-isopropyl-1,3-thiazol-2-yl)-2-methoxybenzenesulfonamide 【CA登记号】 |
【 分 子 式 】C13H14BrClN2O3S2 【 分 子 量 】425.75454 【元素组成】C 36.67% H 3.31% Br 18.77% Cl 8.33% N 6.58% O 11.27% S 15.06% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Acylation of 2-amino-4-chloro-5-isopropylthiazole (I) with 5-bromo-2-methoxybenzenesulfonyl chloride (II) yields sulfonamide (III). Methylation of (III) with ICH3/NaH takes place at the thiazole N, producing (IV). Finally, methyl ether cleavage in (IV) by means of BBr3 in cold CHCl3 affords the title compound.
| 【1】 Yamamoto, O.; Fujii, M.; Ohgami, T.; et al.; Synthesis and structure-activity relationships of novel non-nucleoside HIV-1 reverse transcriptase inhibitors. 42nd Intersci Conf Antimicrob Agents Chemother (Sept 27 2002, San Diego) 2002, Abst F-1700. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 61997 | 4-chloro-5-isopropyl-1,3-thiazol-2-amine; 4-chloro-5-isopropyl-1,3-thiazol-2-ylamine | C6H9ClN2S | 详情 | 详情 | |
| (II) | 56273 | 5-Bromo-2-methoxybenzenesulfonyl chloride | 23095-05-8 | C7H6BrClO3S | 详情 | 详情 |
| (III) | 61998 | 5-bromo-N-(4-chloro-5-isopropyl-1,3-thiazol-2-yl)-2-methoxybenzenesulfonamide | C13H14BrClN2O3S2 | 详情 | 详情 | |
| (IV) | 61999 | 5-bromo-N-[4-chloro-5-isopropyl-3-methyl-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzenesulfonamide | C14H16BrClN2O3S2 | 详情 | 详情 |
Extended Information