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【结 构 式】 
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【分子编号】61994 【品名】3-(benzyloxy)-N-{3-[(4-{[3-({[3-(benzyloxy)-1-methyl-2-oxo-1,2-dihydro-4-pyridinyl]carbonyl}amino)propyl]amino}butyl)amino]propyl}-1-methyl-2-oxo-1,2-dihydro-4-pyridinecarboxamide 【CA登记号】 |
【 分 子 式 】C38H48N6O6 【 分 子 量 】684.83596 【元素组成】C 66.65% H 7.06% N 12.27% O 14.02% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VII)Acylation of the primary amino groups of spermine (V) by the N acyl thiazolide (VI) furnishes diamide (VII). This is further coupled with acid chloride (IV) producing tetraamide (VIII). Finally, deprotection of the O-benzyl groups under acidic conditions gives rise to the title compound.
| 【1】 Xu, J.; et al.; Synthesis and initial evaluation for in vivo chelation of Pu(IV) of a mixed octadentate spermine-based ligand containing 4-carbamoyl-3-hydroxy-1-methyl-2(1H)-pyridinone and 6-carbamoyl-1-hydroxy-2(1H)-pyridinone. J Med Chem 2002, 45, 18, 3963. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IV) | 61993 | 1-(benzyloxy)-6-oxo-1,6-dihydro-2-pyridinecarbonyl chloride | C13H10ClNO3 | 详情 | 详情 | |
| (V) | 46326 | N-(3-aminopropyl)-N-[4-[(3-aminopropyl)amino]butyl]amine; N(1),N(4)-bis(3-aminopropyl)-1,4-butanediamine | C10H26N4 | 详情 | 详情 | |
| (VI) | 48345 | 3-(benzyloxy)-1-methyl-4-[(2-thioxo-1,3-thiazolidin-3-yl)carbonyl]-2(1H)-pyridinone | C17H16N2O3S2 | 详情 | 详情 | |
| (VII) | 61994 | 3-(benzyloxy)-N-{3-[(4-{[3-({[3-(benzyloxy)-1-methyl-2-oxo-1,2-dihydro-4-pyridinyl]carbonyl}amino)propyl]amino}butyl)amino]propyl}-1-methyl-2-oxo-1,2-dihydro-4-pyridinecarboxamide | C38H48N6O6 | 详情 | 详情 | |
| (VIII) | 61995 | 1-(benzyloxy)-N-[3-({[3-(benzyloxy)-1-methyl-2-oxo-1,2-dihydro-4-pyridinyl]carbonyl}amino)propyl]-N-[4-([3-({[3-(benzyloxy)-1-methyl-2-oxo-1,2-dihydro-4-pyridinyl]carbonyl}amino)propyl]{[1-(benzyloxy)-6-oxo-1,6-dihydro-2-pyridinyl]carbonyl}amino)but | C64H66N8O12 | 详情 | 详情 |
Extended Information