1-hydroxy-6-oxo-1,6-dihydro-2-pyridinecarboxylic acid -Drug Synthesis Database

【结构式】

【分子编号】61991

【品名】1-hydroxy-6-oxo-1,6-dihydro-2-pyridinecarboxylic acid

【CA登记号】

【分子式】C₆H₅NO₄

【分子量】155.11004

【元素组成】C 46.46% H 3.25% N 9.03% O 41.26%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

6-Hydroxypicolinic acid (I) is oxidized to the N-hydroxy pyridinone (II) employing peracetic acid (obtained by mixing Ac2O and H2O2) in the presence of TFA. Protection of the N-hydroxy group of (II) with benzyl chloride affords the N-benzyloxy pyridinone (III). The carboxy group of (III) is then activated as the corresponding acid chloride (IV) by treatment with oxalyl chloride.

参考文献中间体

合成目标

【1】 Xu, J.; et al.; Synthesis and initial evaluation for in vivo chelation of Pu(IV) of a mixed octadentate spermine-based ligand containing 4-carbamoyl-3-hydroxy-1-methyl-2(1H)-pyridinone and 6-carbamoyl-1-hydroxy-2(1H)-pyridinone. J Med Chem 2002, 45, 18, 3963.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	61990	6-hydroxy-2-pyridinecarboxylic acid	C₆H₅NO₃	详情	详情
(II)	61991	1-hydroxy-6-oxo-1,6-dihydro-2-pyridinecarboxylic acid	C₆H₅NO₄	详情	详情
(III)	61992	1-(benzyloxy)-6-oxo-1,6-dihydro-2-pyridinecarboxylic acid	C₁₃H₁₁NO₄	详情	详情
(IV)	61993	1-(benzyloxy)-6-oxo-1,6-dihydro-2-pyridinecarbonyl chloride	C₁₃H₁₀ClNO₃	详情	详情

Extended Information