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【结 构 式】 
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【分子编号】61738 【品名】(7S)-2-(acetyloxy)-14-[tert-butyl(dimethyl)silyl]-7-ethyl-8,11-dioxo-7,8,9,10,11,13-hexahydrobenzo[6,7]indolizino[1,2-b]quinolin-7-yl acetate 【CA登记号】 |
【 分 子 式 】C31H36N2O6Si 【 分 子 量 】560.72222 【元素组成】C 66.4% H 6.47% N 5% O 17.12% Si 5.01% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VI)The reaction of 10-hydroxycamptothecin (IV) with Ac2O and pyridine gives the diacetate (V), which is silylated with Tbdms-H, (t-BuO)2 and Tis-SH in refluxing dioxane/TFA to give the silylated diacetate (VI). Finally, this compound is deacetylated by reaction with NaOMe in methanol or HCl in ethanol to afford the target silylated 10-hydroxycamptothecin.
| 【1】 Du, W.; Kaskar, B.; Blumbergs, P.; Subramanian, P.-K.; Curran, D.P.; Semisynthesis of DB-67 and other silatecans from camptothecin by thiol-promoted addition of silyl radicals. Bioo. & Med. Chem. 2003, 11, 39, 451. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IV) | 61736 | (7S)-7-ethyl-2,7-dihydroxy-10,13-dihydrobenzo[6,7]indolizino[1,2-b]quinoline-8,11(7H,9H)-dione | C21H18N2O4 | 详情 | 详情 | |
| (V) | 61737 | (7S)-2-(acetyloxy)-7-ethyl-8,11-dioxo-7,8,9,10,11,13-hexahydrobenzo[6,7]indolizino[1,2-b]quinolin-7-yl acetate | C25H22N2O6 | 详情 | 详情 | |
| (VI) | 61738 | (7S)-2-(acetyloxy)-14-[tert-butyl(dimethyl)silyl]-7-ethyl-8,11-dioxo-7,8,9,10,11,13-hexahydrobenzo[6,7]indolizino[1,2-b]quinolin-7-yl acetate | C31H36N2O6Si | 详情 | 详情 |
Extended Information