【结 构 式】 |
【分子编号】61668 【品名】tert-butyl 2-[(tert-butoxycarbonyl)amino]-3-fluoro-2-methylpropanoate 【CA登记号】 |
【 分 子 式 】C13H24FNO4 【 分 子 量 】277.3363032 【元素组成】C 56.3% H 8.72% F 6.85% N 5.05% O 23.08% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(V)The nonradioactive aminoacid is prepared as follows. The Strecker reaction of fluoroacetone (I) with KCN and NH4Cl provides amino nitrile (II). Acid hydrolysis of (II) gives aminoacid (III), which is further protected as the N-Boc derivative (IV) by using di-t-butyl dicarbonate. Treatment of acid (IV) with t-butyl trichloroacetimidate produces the t-butyl ester (V). Subsequent alkylation of (V) with iodomethane and NaH affords the N-methyl derivative (VI). The protecting groups of (VI) are finally removed by acidic hydrolysis to produce the free aminoacid.
【1】 McConathy, J.; et al.; Radiolabeled amino acids for tumor imaging with PET: Radiosynthesis and biological evaluation of 2-amino-3[18F]fluoro-2-methylpropanoic acid and 3-[18F]fluoro-2-methyl-2-(methylamino)propanoic acid. J Med Chem 2002, 45, 11, 2240. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(A) | 61667 | tert-butyl 2,2,2-trichloroethanimidoate | C6H10Cl3NO | 详情 | 详情 | |
(I) | 61762 | Fluoroacetone; 2-Propanone, 1-fluoro-; Fluoroacetone; mono-FLUOROACETONE | 430-51-3 | C3H5FO | 详情 | 详情 |
(II) | 61763 | tert-butyl (3S)-3-[(acetyloxy)methyl]-6-(benzyloxy)-5-{[(E)-3-methoxy-1-methyl-3-oxo-1-propenyl]amino}-2,3-dihydro-1H-indole-1-carboxylate | C4H7FN2 | 详情 | 详情 | |
(III) | 61764 | 3-fluoro-2-methylalanine | C4H8FNO2 | 详情 | 详情 | |
(IV) | 61666 | N-(tert-butoxycarbonyl)-3-fluoro-2-methylalanine | C9H16FNO4 | 详情 | 详情 | |
(V) | 61668 | tert-butyl 2-[(tert-butoxycarbonyl)amino]-3-fluoro-2-methylpropanoate | C13H24FNO4 | 详情 | 详情 | |
(VI) | 61669 | tert-butyl 2-[(tert-butoxycarbonyl)(methyl)amino]-3-fluoro-2-methylpropanoate | C14H26FNO4 | 详情 | 详情 |
Extended Information