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【结 构 式】 
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【分子编号】61656 【品名】 【CA登记号】 |
【 分 子 式 】C81H134N14Na2O27 【 分 子 量 】1782.012656 【元素组成】C 54.6% H 7.58% N 11% Na 2.58% O 24.24% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)The known N-(2-hydroxypropyl)-methacrylamide copolymer (I) which has a p-nitrophenyl peptide side chain is coupled to ethyl aminomalonate (II) in the presence of Et3N in DMF to give the corresponding amide (III). Alkaline hydrolysis of the diethyl malonate ester groups of (III) affords the sodium carboxylate salt (IV). This is then complexed with the platinum species, generated in situ from cisplatin (V) and silver nitrate, to produce the title polymer-linked platinum complex.
| 【1】 Duncan, R.; Evagorou, E.G.; Buckley, R.G.; Gianasi, E. (Access Pharmaceuticals, Inc.); Polymer-platinum cpds.. WO 9847537 . |
Extended Information