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【结 构 式】

【分子编号】61500

【品名】4-(benzyloxy)-3,5-dichlorobenzoic acid

【CA登记号】

【 分 子 式 】C14H10Cl2O3

【 分 子 量 】297.137

【元素组成】C 56.59% H 3.39% Cl 23.86% O 16.15%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

Synthesis of the iodopropionic intermediate (IV) is achieved as follows. The condensation of 4-benzyloxy-3,5-dichlorobenzoic acid (I) with L-serine benzyl ester (II) by means of BOP and TEA in dichloromethane gives the benzoyl-serine (III), which is then converted into the target iodopropionic intermediate (IV) by reaction with MsCl and TEA, followed by treatment with NaI in acetone.

1 Watanabe, H.; Okue, M.; Kobayashi, H.; Kitahara, T.; The first synthesis of kaitocephalin based on the structure revision. Tetrahedron Lett 2002, 43, 5, 861.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 61500 4-(benzyloxy)-3,5-dichlorobenzoic acid C14H10Cl2O3 详情 详情
(II) 38229 benzyl (2S)-2-amino-3-hydroxypropanoate C10H13NO3 详情 详情
(III) 61501 benzyl (2S)-2-{[4-(benzyloxy)-3,5-dichlorobenzoyl]amino}-3-hydroxypropanoate C24H21Cl2NO5 详情 详情
(IV) 61502 benzyl (2R)-2-{[4-(benzyloxy)-3,5-dichlorobenzoyl]amino}-3-iodopropanoate C24H20Cl2INO4 详情 详情
Extended Information