2-amino-6-sulfanyl-4-pyrimidinol -Drug Synthesis Database

【结构式】

【分子编号】61480

【品名】2-amino-6-sulfanyl-4-pyrimidinol

【CA登记号】

【分子式】C₄H₅N₃OS

【分子量】143.16932

【元素组成】C 33.56% H 3.52% N 29.35% O 11.18% S 22.4%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VII)

Displacement of the triflate group of (VI) with the pyrimidinyl thiol (VII) yields the vinyl sulfide (VIII). Then, deprotection of (VIII) by means of trifluoroacetic acid and triethylsilane gives rise to the title compound

参考文献中间体

合成目标

【1】 Lee, C.; Kim, G.; Jang, Y.; Koo, K.; Cho, Y.; Youn, H.; Synthesis and antibacterial activities of LB11058, a novel anti-MRSA cephalosporin antibiotic. 42nd Intersci Conf Antimicrob Agents Chemother (Sept 27 2002, San Diego) 2002, Abst F-329.
【2】 Lee, S.-H.; Lee, C.-S.; Ryu, E.-J.; Jang, Y.-J.; Kim, G.-T.; Cho, Y.-r.; Joo, H.-Y.; Shin, J.-E.; Koo, K.-D. (LG Chem Ltd.); Novel cephalosporin cpds. and process for preparing the same. WO 0372582 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(VI)	61479	benzhydryl (6R,7R)-7-({2-{2-[(tert-butoxycarbonyl)amino]-5-chloro-1,3-thiazol-4-yl}-2-[(trityloxy)imino]acetyl}amino)-8-oxo-3-((E)-2-{[(trifluoromethyl)sulfonyl]oxy}ethenyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate	C₅₂H₄₃ClF₃N₅O₁₀S₃	详情	详情
(VII)	61480	2-amino-6-sulfanyl-4-pyrimidinol	C₄H₅N₃OS	详情	详情
(VIII)	61481	benzhydryl (6R,7R)-3-{(E)-2-[(2-amino-6-hydroxy-4-pyrimidinyl)sulfanyl]ethenyl}-7-({2-{2-[(tert-butoxycarbonyl)amino]-5-chloro-1,3-thiazol-4-yl}-2-[(trityloxy)imino]acetyl}amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate	C₅₅H₄₇ClN₈O₈S₃	详情	详情

Extended Information