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【结 构 式】 
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【分子编号】61461 【品名】allyl (4R,5S,6S)-3-[(4-{1-[(allyloxy)carbonyl]-2,5-dihydro-1H-pyrrol-3-yl}-1,3-thiazol-2-yl)sulfanyl]-4-methyl-7-oxo-6-{(1R)-1-[(trimethylsilyl)oxy]ethyl}-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 【CA登记号】 |
【 分 子 式 】C27H35N3O6S2Si 【 分 子 量 】589.80902 【元素组成】C 54.98% H 5.98% N 7.12% O 16.28% S 10.87% Si 4.76% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIII)Coupling of the carbapenem phosphate (XII) with mercaptothiazole (XI) furnishes thioether (XIII). Finally, desilylation of (XIII), followed by palladium-catalyzed removal of the allyl ester and carbamate groups provides the title compound
| 【1】 Sunagawa, M.; Itoh, M.; Kubota, K.; et al.; New anti-MRSA and anti-VRE carbapenems; synthesis and structure-activity relationships of 1beta-methyl-2-(thiazol-2-ylthio)carbapenems. J. Antibiot. 2002, 55, 8, 722. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XI) | 61459 | allyl 3-(2-sulfanyl-1,3-thiazol-4-yl)-2,5-dihydro-1H-pyrrole-1-carboxylate | C11H12N2O2S2 | 详情 | 详情 | |
| (XII) | 61460 | allyl (4R,5R,6S)-3-[(diphenoxyphosphoryl)oxy]-4-methyl-7-oxo-6-{(1R)-1-[(trimethylsilyl)oxy]ethyl}-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate | C28H34NO8PSi | 详情 | 详情 | |
| (XIII) | 61461 | allyl (4R,5S,6S)-3-[(4-{1-[(allyloxy)carbonyl]-2,5-dihydro-1H-pyrrol-3-yl}-1,3-thiazol-2-yl)sulfanyl]-4-methyl-7-oxo-6-{(1R)-1-[(trimethylsilyl)oxy]ethyl}-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate | C27H35N3O6S2Si | 详情 | 详情 |
Extended Information