【结 构 式】 |
【分子编号】61403 【品名】(2S)-1-{(2S,5S,8S,11S,14R,17S)-11-[(1R)-1-(tert-butoxy)ethyl]-2-{3-[(imino{[(2,2,5,7,8-pentamethyl-3,4,4a,8a-tetrahydro-2H-chromen-6-yl)sulfonyl]amino}methyl)amino]propyl}-17-isopropyl-24-methyl-5,14-bis[(1S)-1-methylpropyl]-4,7,10,13,16,19,22,25-octaoxo-8-propyl-3,6,9,12,15,18,21,24-octaazahexacos-1-anoyl}-2-pyrrolidinecarboxylic acid 【CA登记号】 |
【 分 子 式 】C62H106N12O15S 【 分 子 量 】1291.66152 【元素组成】C 57.65% H 8.27% N 13.01% O 18.58% S 2.48% |
合成路线1
该中间体在本合成路线中的序号:(XIX)Coupling of resin (XVI) with N-Fmoc-sarcosine (XVII), followed by treatment with piperidine, provides (XVIII). This is treated with acetic acid and HBTU, producing the N-acetylated peptide resin (XIX). Cleavage of (XIX) from the resin in the presence of ethylamine leads to the side-chain protected peptide amide (XX).
【1】 Haviv, F.; Kalvin, D.M.; Henkin, J.; Bradley, M.F.; Schneider, A.J. (Abbott Laboratories Inc.); Peptide antiangiogenic drugs. JP 2002516342; WO 9961476 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(XVI) | 61401 | (2S)-1-{(2S,5S,8S,11S,14R,17S)-20-amino-11-[(1R)-1-(tert-butoxy)ethyl]-2-{3-[(imino{[(2,2,5,7,8-pentamethyl-3,4,4a,8a-tetrahydro-2H-chromen-6-yl)sulfonyl]amino}methyl)amino]propyl}-17-isopropyl-5,14-bis[(1S)-1-methylpropyl]-4,7,10,13,16,19-hexaoxo-8-propyl-3,6,9,12,15,18-hexaazaicos-1-anoyl}-2-pyrrolidinecarboxylic acid | C57H99N11O13S | 详情 | 详情 | |
(XVII) | 52441 | 2-[{[(9H-fluoren-9-ylmethyl)oxy]carbonyl}(methyl)amino]acetic acid | C18H17NO4 | 详情 | 详情 | |
(XVIII) | 61402 | (2S)-1-{(2S,5S,8S,11S,14R,17S)-11-[(1R)-1-(tert-butoxy)ethyl]-2-{3-[(imino{[(2,2,5,7,8-pentamethyl-3,4,4a,8a-tetrahydro-2H-chromen-6-yl)sulfonyl]amino}methyl)amino]propyl}-17-isopropyl-5,14-bis[(1S)-1-methylpropyl]-4,7,10,13,16,19,22-heptaoxo-8-propyl-3,6,9,12,15,18,21,24-octaazapentacos-1-anoyl}-2-pyrrolidinecarboxylic acid | C60H104N12O14S | 详情 | 详情 | |
(XIX) | 61403 | (2S)-1-{(2S,5S,8S,11S,14R,17S)-11-[(1R)-1-(tert-butoxy)ethyl]-2-{3-[(imino{[(2,2,5,7,8-pentamethyl-3,4,4a,8a-tetrahydro-2H-chromen-6-yl)sulfonyl]amino}methyl)amino]propyl}-17-isopropyl-24-methyl-5,14-bis[(1S)-1-methylpropyl]-4,7,10,13,16,19,22,25-octaoxo-8-propyl-3,6,9,12,15,18,21,24-octaazahexacos-1-anoyl}-2-pyrrolidinecarboxylic acid | C62H106N12O15S | 详情 | 详情 | |
(XX) | 61404 | (2S)-1-{(2S,5S,8S,11S,14R,17S)-11-[(1R)-1-(tert-butoxy)ethyl]-2-{3-[(imino{[(2,2,5,7,8-pentamethyl-3,4,4a,8a-tetrahydro-2H-chromen-6-yl)sulfonyl]amino}methyl)amino]propyl}-17-isopropyl-24-methyl-5,14-bis[(1S)-1-methylpropyl]-4,7,10,13,16,19,22,25-oc | C64H111N13O14S | 详情 | 详情 |