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【结 构 式】

【分子编号】61373

【品名】5-chloro-2-[(3-methyl-5-isoxazolyl)methoxy]benzylamine; {5-chloro-2-[(3-methyl-5-isoxazolyl)methoxy]phenyl}methanamine

【CA登记号】

【 分 子 式 】C12H13ClN2O2

【 分 子 量 】252.7002

【元素组成】C 57.04% H 5.19% Cl 14.03% N 11.09% O 12.66%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XVI)

Coupling between 2-(phthalimidomethyl)-4-chlorophenol (XIII) and 5-(hydroxymethyl)-3-methylisoxazole (XIV) under Mitsunobu conditions provides the ether adduct (XV). Subsequent phthaloyl group hydrazinolysis in (XV) leads to the primary amine (XVI). The 6-chloropurine glycoside (XII) is then condensed with amine (XVI) to furnish the 6-aminopurine derivative (XVII). Finally, Boc group cleavage in (XVII) employing methanesulfonic acid affords the title compound.

1 Masamune, H.; Scott, R.W.; Deninno, M.P. (Pfizer Products Inc.); Cpds. for the treatment of ischemia. EP 1216257; JP 2003510331; WO 0123399 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XII) 61370 tert-butyl (2S,3S,4R,5R)-5-(6-chloro-9H-purin-9-yl)-4-hydroxy-2-[(methylamino)carbonyl]tetrahydro-3-furanylcarbamate C16H21ClN6O5 详情 详情
(XIII) 61371 2-(5-chloro-2-hydroxybenzyl)-1H-isoindole-1,3(2H)-dione C15H10ClNO3 详情 详情
(XIV) 13343 (3-Methyl-5-isoxazolyl)methanol C5H7NO2 详情 详情
(XV) 61372 2-{5-chloro-2-[(3-methyl-5-isoxazolyl)methoxy]benzyl}-1H-isoindole-1,3(2H)-dione C20H15ClN2O4 详情 详情
(XVI) 61373 5-chloro-2-[(3-methyl-5-isoxazolyl)methoxy]benzylamine; {5-chloro-2-[(3-methyl-5-isoxazolyl)methoxy]phenyl}methanamine C12H13ClN2O2 详情 详情
(XVII) 61374 tert-butyl (2S,3S,4R,5R)-5-[6-({5-chloro-2-[(3-methyl-5-isoxazolyl)methoxy]benzyl}amino)-9H-purin-9-yl]-4-hydroxy-2-[(methylamino)carbonyl]tetrahydro-3-furanylcarbamate C28H33ClN8O7 详情 详情
Extended Information