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【结 构 式】 
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【分子编号】60999 【品名】N-[3-imino-3-(methylamino)propyl]-1-isopentyl-4-nitro-1H-pyrrole-2-carboxamide 【CA登记号】 |
【 分 子 式 】C14H23N5O3 【 分 子 量 】309.36852 【元素组成】C 54.35% H 7.49% N 22.64% O 15.51% |
合成路线1
该中间体在本合成路线中的序号：(VIII)Alkylation of ethyl 4-nitropyrrole-2-carboxylate (I) with 3-methylbutyl bromide (II) in the presence of NaOMe affords the N-isoamyl pyrrole (III). Saponification of the ethyl ester group of (III), followed by treatment of the resultant carboxylic acid (IV) with SOCl2 provides acid chloride (V). This is subsequently coupled with 3-aminopropionitrile (VI) to yield the N-(2-cyanoethyl) amide (VII). Conversion of the cyano group of (VII) into the N-methyl amidine (VIII) is then accomplished under Pinner reaction conditions. Reduction of the nitro group of (VIII) by catalytic hydrogenation over Pd/C furnishes the intermediate aminopyrrole (IX).
| 【1】 Roberts, C.D.; Keicher, J.D.; Dyatkina, N.B.; et al.; Minor groove DNA binders as antimicrobial agents. 1. Pyrrole tetraamides are potent antibacterials against vancomycin resistant Enteroccoci and methicillin resistant Staphylococcus aureus. J Med Chem 2002, 45, 4, 805. |
| 【2】 Dyatkina, N.; Hanson, E.; Liehr, S.; et al.; Synthesis, SAR and antimicrobial activity of pyrrole tetraamides. 224th ACS Natl Meet (Aug 18 2002, Boston) 2002, Abst MEDI 62. |
| 【3】 Nelson, P.H.; Muchowski, J.M.; Dyatkina, N.B.; Shi, D.-F.; Zhang, W.; Liehr, S.J.R.; Velligan, M.D.; Botyanszki, J.; Roberts, C.D.; Khorlin, A. (Genelabs Technologies, Inc.); Novel cpds. possessing antibacterial, antifungal or antitumor activity. WO 0200650 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 60988 | 1-methoxy-2,3-dihydro-1H-inden-2-yl methanesulfonate | C11H14O4S | 详情 | 详情 | |
| (II) | 46234 | 1-bromo-3-methylbutane | C5H11Br | 详情 | 详情 | |
| (III) | 54019 | ethyl 1-isopentyl-4-nitro-1H-pyrrole-2-carboxylate | C12H18N2O4 | 详情 | 详情 | |
| (IV) | 54020 | 1-isopentyl-4-nitro-1H-pyrrole-2-carboxylic acid | C10H14N2O4 | 详情 | 详情 | |
| (V) | 54021 | 1-isopentyl-4-nitro-1H-pyrrole-2-carbonyl chloride | C10H13ClN2O3 | 详情 | 详情 | |
| (VI) | 38094 | 3-aminopropanenitrile | 151-18-8 | C3H6N2 | 详情 | 详情 |
| (VII) | 54022 | N-(2-cyanoethyl)-1-isopentyl-4-nitro-1H-pyrrole-2-carboxamide | C13H18N4O3 | 详情 | 详情 | |
| (VIII) | 60999 | N-[3-imino-3-(methylamino)propyl]-1-isopentyl-4-nitro-1H-pyrrole-2-carboxamide | C14H23N5O3 | 详情 | 详情 | |
| (IX) | 61000 | 4-amino-N-[3-imino-3-(methylamino)propyl]-1-isopentyl-1H-pyrrole-2-carboxamide | C14H25N5O | 详情 | 详情 |