[1-(cyclopropylmethyl)-2-pyrrolidinyl]methanamine; [1-(cyclopropylmethyl)-2-pyrrolidinyl]methylamine -Drug Synthesis Database

【结构式】

【分子编号】60997

【品名】[1-(cyclopropylmethyl)-2-pyrrolidinyl]methanamine; [1-(cyclopropylmethyl)-2-pyrrolidinyl]methylamine

【CA登记号】

【分子式】C₃₁H₃₅F₂N₅O₆

【分子量】611.6458064

【元素组成】C 60.88% H 5.77% F 6.21% N 11.45% O 15.69%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XIV)

Condensation of piperidine (XIII) with the N-bromopropyl derivative (VI) gives rise to the title compound. Alternatively, the title compound can be prepared by condensation of bromide (VI) with tetrahydropyridine (XI) to produce adduct (XIV), which is then hydrogenated over Pd/C.

参考文献中间体

合成目标

【1】 Gluchowski, C.; Chiu, G.; Marzabadi, M.R.; Nagarathnam, D.; Lagu, B.; Noble, S.; Wetzel, J.; Deleon, J.E. (Synaptic Pharmaceutical Corp.); Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof. EP 1299362; WO 0206245 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(VI)	60991	methyl (4S)-3-{[(3-bromopropyl)amino]carbonyl}-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate	C₁₈H₂₀BrF₂N₃O₅	详情	详情
(XI)	60994	N-[3-(1,2,3,6-tetrahydro-4-pyridinyl)phenyl]acetamide	C₁₃H₁₆N₂O	详情	详情
(XIII)	60996	N-[3-(4-piperidinyl)phenyl]acetamide	C₁₃H₁₈N₂O	详情	详情
(XIV)	60997	[1-(cyclopropylmethyl)-2-pyrrolidinyl]methanamine; [1-(cyclopropylmethyl)-2-pyrrolidinyl]methylamine	C₃₁H₃₅F₂N₅O₆	详情	详情

Extended Information