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【结 构 式】

【分子编号】60944

【品名】2-(methylsulfanyl)phenyl 2-oxiranylmethyl ether; 2-{[2-(methylsulfanyl)phenoxy]methyl}oxirane

【CA登记号】

【 分 子 式 】C10H12O2S

【 分 子 量 】196.27008

【元素组成】C 61.2% H 6.16% O 16.3% S 16.34%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The condensation of o-(methylthio)phenol (I) with epichlorohydrin (II) by means of sodium hydroxide in water gives 3-[o-(methylthio)phenoxy]-1,2-epoxypropane (III), which is then treated with isopropylamine (IV) in hot water and finally with ethanolic HCl

1 (N.V. Philips' Gloeilampenfabrieken); BE 679005; CA 832495; DE 1543790; FR 1552786; FR 6393; GB 1137764; JP 6902978; NL 6504268; US 3542874; US 3632780 .
2 Blancafort, P.; Serradell, M.N.; Castaner, J.; Weetman, D.F.; Tiprenolol hydrochloride. Drugs Fut 1979, 4, 11, 830.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 28075 2-(methylsulfanyl)phenol 1073-29-6 C7H8OS 详情 详情
(II) 10146 Epichlorohydrin; 2-(Chloromethyl)oxirane 106-89-8 C3H5ClO 详情 详情
(III) 60944 2-(methylsulfanyl)phenyl 2-oxiranylmethyl ether; 2-{[2-(methylsulfanyl)phenoxy]methyl}oxirane C10H12O2S 详情 详情
(IV) 23933 2-Propanamine; Isopropylamine 75-31-0 C3H9N 详情 详情
(V) 60945 1-(isopropylamino)-3-[2-(methylsulfanyl)phenoxy]-2-propanol C13H21NO2S 详情 详情
Extended Information