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【结 构 式】

【分子编号】60942

【品名】3-(4-bromophenyl)-3-hydroxy-N-methyl-3-(3-pyridinyl)propanamide

【CA登记号】

【 分 子 式 】C15H15BrN2O2

【 分 子 量 】335.20038

【元素组成】C 53.75% H 4.51% Br 23.84% N 8.36% O 9.55%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VI)

The condensation of 4-bromophenyl-3-pyridyl ketone (I) with ethyl bromoacetate (II) by means of Zn in refluxing benzene gives ethyl 3-hydroxy-3-(3-pyridyl)-3-(4-bromophenyl)propionate (III), which is converted into the corresponding methylamide (VI) by treatment with methylamine (V) in ethanol. This compound is reduced with NaBH4 in THF yielding 3-(3-pyridyl)-3-(4-bromophenyl)-3-hydroxy-N-methylpropylamine (VII), which is finally dehydrated by treatment with 50% H2SO4 at 110 C

1 Blancafort, P.; Serradell, M.N.; Castaner, J.; Sweetman, A.J.; Nomelidine. Drugs Fut 1979, 4, 12, 885.
2 Carlsson, P.A.E.; et al. (Astra Lakemedel AB); BE 835802; DD 122528; DE 2550005; FR 2291751; JP 7676278; NL 7513648; ZA 7506893 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 60939 (4-bromophenyl)(3-pyridinyl)methanone C12H8BrNO 详情 详情
(II) 16640 Ethyl 2-bromoacetate; Ethyl bromoacetate 105-36-2 C4H7BrO2 详情 详情
(III) 60940 ethyl 3-(4-bromophenyl)-3-hydroxy-3-(3-pyridinyl)propanoate C16H16BrNO3 详情 详情
(V) 11021 Methanamine; Methylamine 74-89-5 CH5N 详情 详情
(VI) 60942 3-(4-bromophenyl)-3-hydroxy-N-methyl-3-(3-pyridinyl)propanamide C15H15BrN2O2 详情 详情
(VII) 60943 1-(4-bromophenyl)-3-(methylamino)-1-(3-pyridinyl)-1-propanol C15H17BrN2O 详情 详情
Extended Information