3,5-dichloro-2-methoxyaniline; 3,5-dichloro-2-methoxyphenylamine -Drug Synthesis Database

【结构式】

【分子编号】60883

【品名】3,5-dichloro-2-methoxyaniline; 3,5-dichloro-2-methoxyphenylamine

【CA登记号】

【分子式】C₇H₇Cl₂NO

【分子量】192.04412

【元素组成】C 43.78% H 3.67% Cl 36.92% N 7.29% O 8.33%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VI)

Alkylation of 2,4-dichloro-6-nitrophenol (IV) with iodomethane in the presence of K2CO3 provides the methyl ether (V). Subsequent nitro group reduction in (V) employing iron powder and NH4Cl leads to aniline (VI). This is then acylated by sulfonyl chloride (III) to form sulfonamide (VII). The N-trichloroacetyl group of (VII) is finally removed by alkaline hydrolysis to provide the title compound

参考文献中间体

合成目标

【1】 Bromidge, S.M.; Moss, S.F. (GlaxoSmithKline plc); N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-piperazin-1-yl-benzenesulfonamide. EP 1313720; WO 0218358 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(III)	48008	4-methoxy-3-[4-(2,2,2-trichloroacetyl)-1-piperazinyl]benzenesulfonyl chloride	C₁₃H₁₄Cl₄N₂O₄S	详情	详情
(IV)	60881	2,4-dichloro-6-nitrophenol	C₆H₃Cl₂NO₃	详情	详情
(V)	60882	2,4-dichloro-6-nitrophenyl methyl ether; 1,5-dichloro-2-methoxy-3-nitrobenzene	C₇H₅Cl₂NO₃	详情	详情
(VI)	60883	3,5-dichloro-2-methoxyaniline; 3,5-dichloro-2-methoxyphenylamine	C₇H₇Cl₂NO	详情	详情
(VII)	60884	N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-[4-(2,2,2-trichloroacetyl)-1-piperazinyl]benzenesulfonamide	C₂₀H₂₀Cl₅N₃O₅S	详情	详情

Extended Information