【结 构 式】 |
【分子编号】60846 【品名】3-cyano-4-hydroxybenzoic acid 【CA登记号】 |
【 分 子 式 】C8H5NO3 【 分 子 量 】163.13264 【元素组成】C 58.9% H 3.09% N 8.59% O 29.42% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(IV)Methyl 4-hydroxybenzoate (I) is iodinated by means of iodine monochloride in hot AcOH, producing (II). Displacement of the aryl iodide (II) with CuCN gives nitrile (III). Then, ester group saponification in (III) leads to 3-cyano-4-hydroxybenzoic acid (IV). Coupling of (IV) with tert-butyl carbazate produces the N-Boc hydrazide (V), which is further deprotected to (VI) by treatment with trifluoroacetic acid
【1】 Ling, A.; Plewe, M.; Gonzalez, J.; et al.; Human glucagon receptor antagonists based on alkylidene hydrazides. Bioorg Med Chem Lett 2002, 12, 4, 663. |
【2】 Gonzales, J.; Sams, C.; Teng, M. (Alanex Corp.; Novo Nordisk A/S); Glucagon antagonists/inverse agonists. EP 0994848; WO 9901423 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 10251 | methyl 4-hydroxybenzoate; Methyl p-hydroxybenzoate | 99-76-3 | C8H8O3 | 详情 | 详情 |
(II) | 60844 | methyl 4-hydroxy-3-iodobenzoate | C8H7IO3 | 详情 | 详情 | |
(III) | 60845 | methyl 3-cyano-4-hydroxybenzoate | C9H7NO3 | 详情 | 详情 | |
(IV) | 60846 | 3-cyano-4-hydroxybenzoic acid | C8H5NO3 | 详情 | 详情 | |
(V) | 60847 | tert-butyl 2-(3-cyano-4-hydroxybenzoyl)-1-hydrazinecarboxylate | C13H15N3O4 | 详情 | 详情 | |
(VI) | 60848 | 3-cyano-4-hydroxybenzohydrazide | C8H7N3O2 | 详情 | 详情 |
Extended Information