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【结 构 式】 
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【分子编号】60776 【品名】5-(4-fluorophenyl)tetrahydro-2-furanol 【CA登记号】 |
【 分 子 式 】C10H11FO2 【 分 子 量 】182.1945432 【元素组成】C 65.92% H 6.09% F 10.43% O 17.56% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VII)The chlorination of N,N-bis(4-fluorophenyl)urea (I) gives N,N-bis(4-fluorophenyl)-N'-chlorourea (II), which by reaction with sodium methoxide is converted into N,N-bis(4-fluorophenyl)-N-(methoxycarbony)hydrazine (III). Hydrolytic decarboxylation of (III) affords N,N-bis(4-fluorophenyl)hydrazine (IV), which is cyclocondensed with N-benzoyl-4-piperidone (V) yielding 8-fluoro-5-(4-fluorophenyl)-1,2,3,4-tetrahydro-gamma-carboline (VI). Finally this compound is condensed with 5-(4-fluorophenyl)-2-hydroxytetrahydrofuran (VII).
| 【1】 EP 900197 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 60770 | N,N-bis(4-fluorophenyl)urea | C13H10F2N2O | 详情 | 详情 | |
| (II) | 60771 | N'-chloro-N,N-bis(4-fluorophenyl)urea | C13H9ClF2N2O | 详情 | 详情 | |
| (III) | 60772 | methyl 2,2-bis(4-fluorophenyl)-1-hydrazinecarboxylate | C14H12F2N2O2 | 详情 | 详情 | |
| (IV) | 60773 | 1,1-bis(4-fluorophenyl)hydrazine | C12H10F2N2 | 详情 | 详情 | |
| (V) | 60774 | 1-benzoyl-4-piperidinone | C12H13NO2 | 详情 | 详情 | |
| (VI) | 60775 | 8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole | C17H14F2N2 | 详情 | 详情 | |
| (VII) | 60776 | 5-(4-fluorophenyl)tetrahydro-2-furanol | C10H11FO2 | 详情 | 详情 |
Extended Information