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【结 构 式】 
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【分子编号】60769 【品名】N-(2-aminoethyl)benzamide 【CA登记号】 |
【 分 子 式 】C9H12N2O 【 分 子 量 】164.20716 【元素组成】C 65.83% H 7.37% N 17.06% O 9.74% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VII)Benclonidine has been synthesized by various routes: 1) Condensation of 1-benzoylimidazolidin-2-one (II) [obtained by reaction of imidazolidin-2-one (I) with benzoyl chloride (A)] and 2,6-dichloroaniline (III) in the presence of phosphoroxy chloride at elevated temperature yields title compound. (1) 2) Clonidine (IV) reacts with benzoylimidazole (V) in aprotic solvents to give directly benclonidine. (2) 3) 2,6-Dichlorophenylisocyanide dichloride (VI) and benzoylethylenediamine (VII) are condensed in the presence of an acid acceptor to give benclonidine. (2)
| 【1】 Franzmair, R.; Pittner, H. (Chemie Linz AG); AU 333749 . |
| 【2】 Franzmair, R. (Chemie Linz AG); AU 339897 . |
| 【3】 Koch, H.; Benclonidine. Drugs Fut 1984, 9, 6, 408. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 10463 | Benzoyl chloride | 98-88-4 | C7H5ClO | 详情 | 详情 |
| (I) | 36228 | 2-imidazolidinone | 120-93-4 | C3H6N2O | 详情 | 详情 |
| (II) | 60764 | 1-benzoyl-2-imidazolidinone | C10H10N2O2 | 详情 | 详情 | |
| (III) | 60765 | 2,6-dichloroaniline; 2,6-dichlorophenylamine | C6H5Cl2N | 详情 | 详情 | |
| (IV) | 60767 | 2,6-dichloro-N-(2-imidazolidinylidene)aniline; N-(2,6-dichlorophenyl)-N-(2-imidazolidinylidene)amine | C9H9Cl2N3 | 详情 | 详情 | |
| (V) | 60766 | 1H-imidazol-1-yl(phenyl)methanone | C10H8N2O | 详情 | 详情 | |
| (VI) | 60768 | 1,3-dichloro-2-[(dichloromethylene)amino]benzene | C7H3Cl4N | 详情 | 详情 | |
| (VII) | 60769 | N-(2-aminoethyl)benzamide | C9H12N2O | 详情 | 详情 |
Extended Information