• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】60752

【品名】N-[5-{2-[benzyl(tert-butyl)amino]acetyl}-2-(benzyloxy)phenyl]urea

【CA登记号】

【 分 子 式 】C27H31N3O3

【 分 子 量 】445.56156

【元素组成】C 72.78% H 7.01% N 9.43% O 10.77%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VI)

The reaction of 3-amino-4-benzyloxyacetophenone (I) with phosgene in toluene gives 3-isocyanate-4-benzyloxyacetophenone (II), which by reaction with ammonia in benzene yields 4-benzyloxy-3-ureidoacetophenone (III). The bromination of this product with Br2 in CHCl3 affords 4-benzyloxy-3-ureidophenacyl bromide (IV), amorphous product that is condensed with N-benzyl-N-tert-butylamine (V) in acetonitrile giving 4-benzyloxy-3-ureido-alpha-(N-benzyl-N-tert-butylamine)acetophenone hydrochloride (VI), m.p. 220-1 C. This product is finally hydrogenated with H2 over Pd/C in methanol

1 Castaner, J.; Sungurbey, K.; Carbuterol. Drugs Fut 1976, 1, 9, 412.
2 Kaiser C.; et al. (Smith Kline French); DE 2106620 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 20628 1-[3-amino-4-(benzyloxy)phenyl]-1-ethanone C15H15NO2 详情 详情
(II) 60749 1-[4-(benzyloxy)-3-isocyanatophenyl]-1-ethanone C16H13NO3 详情 详情
(III) 60750 N-[5-acetyl-2-(benzyloxy)phenyl]urea C16H16N2O3 详情 详情
(IV) 60751 N-[2-(benzyloxy)-5-(2-bromoacetyl)phenyl]urea hydrobromide C16H16Br2N2O3 详情 详情
(V) 24700 N-benzyl-2-methyl-2-propanamine 3378-72-1 C11H17N 详情 详情
(VI) 60752 N-[5-{2-[benzyl(tert-butyl)amino]acetyl}-2-(benzyloxy)phenyl]urea C27H31N3O3 详情 详情
Extended Information