3-acetyl-1-benzothiophen-5-yl benzenesulfonate -Drug Synthesis Database

【结构式】

【分子编号】60671

【品名】3-acetyl-1-benzothiophen-5-yl benzenesulfonate

【CA登记号】

【分子式】C₁₆H₁₂O₄S₂

【分子量】332.40088

【元素组成】C 57.81% H 3.64% O 19.25% S 19.29%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XIII)

In a different method, after protection of 5-hydroxybenzothiophene (XI) as the benzenesulfonate ester (XII), Friedel-Crafts acylation with acetyl chloride and AlCl3 gave ketone (XIII). Haloform reaction on the methyl ketone (XIII) produced the carboxylic acid (VIII), which was further converted to acid chloride (X) by treatment with SOCl2 as above.

参考文献中间体

合成目标

【1】 Hiramatsu, Y.; Honma, T. (Shionogi & Co. Ltd.); Process for producing 5-hydroxybenzo[b]thiophene-3-carboxylic acid derivs.. EP 1069122; WO 9950260 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(VIII)	52696	5-[(phenylsulfonyl)oxy]-1-benzothiophene-3-carboxylic acid	C₁₅H₁₀O₅S₂	详情	详情
(X)	52252	3-(chlorocarbonyl)-1-benzothiophen-5-yl benzenesulfonate	C₁₅H₉ClO₄S₂	详情	详情
(XI)	60669	1-benzothiophen-5-ol	C₈H₆OS	详情	详情
(XII)	60670	1-benzothiophen-5-yl benzenesulfonate	C₁₄H₁₀O₃S₂	详情	详情
(XIII)	60671	3-acetyl-1-benzothiophen-5-yl benzenesulfonate	C₁₆H₁₂O₄S₂	详情	详情

Extended Information