N-(2,3-dihydro-1H-inden-4-yl)thiourea -Drug Synthesis Database

【结构式】

【分子编号】60637

【品名】N-(2,3-dihydro-1H-inden-4-yl)thiourea

【CA登记号】

【分子式】C₁₀H₁₂N₂S

【分子量】192.28476

【元素组成】C 62.46% H 6.29% N 14.57% S 16.68%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

4-Amiomoindan (I) is reacted with benzoylisothiocyanate (II) to give the benzoylthiourea (III), which after hydrolysis of 4-indanyltiourea (IV) is methylated with iodomethane to (V). The free base (VI) is cyclized with ethyldiamine (A) and p-toluenesulfonic acid to indanazoline

参考文献中间体

合成目标

【1】 May, H. J.; Berg, A. (Nordmark-Werke GmbH); BE 786499; CA 967162; DE 2136325; FR 2146430; GB 1346037; JP 7319575; JP 7918260; NL 7209138; SA 7204747; SU 571502; US 3882229 .
【2】 Kirchhoff, T.; Kauff, N.D.; Mitra, N.; et al.; BRCA mutations and risk of prostate cancer in ashkenazi jews. Arzneim-Forsch Drug Res 1980, 30, 9, 1733.
【3】 Unterhalt, B.; Indanazoline Hydrochloride. Drugs Fut 1981, 6, 7, 417.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(A)	14754	ethylenediamine;1,2-Diaminoethane;ethane-1,2-diamine；1,2-Ethanediamine	107-15-3	C₂H₈N₂	详情	详情
(I)	60634	2,3-dihydro-1H-inden-4-ylamine; 4-indanamine		C₉H₁₁N	详情	详情
(II)	23530	benzoyl isothiocyanate	532-55-8	C₈H₅NOS	详情	详情
(III)	60636	N-benzoyl-N'-(2,3-dihydro-1H-inden-4-yl)thiourea		C₁₇H₁₆N₂OS	详情	详情
(IV)	60637	N-(2,3-dihydro-1H-inden-4-yl)thiourea		C₁₀H₁₂N₂S	详情	详情
(V)	60638	(2,3-dihydro-1H-inden-4-ylamino)(methylsulfanyl)methaniminium		C₁₁H₁₅N₂S	详情	详情
(VI)	60639	4-{[imino(methylsulfanyl)methyl]amino}indane		C₁₁H₁₄N₂S	详情	详情

Extended Information