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【结 构 式】 
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【分子编号】60628 【品名】N-(3-aminopropyl)-N-(4-ethoxy-2-quinolinyl)amine; N~1~-(4-ethoxy-2-quinolinyl)-1,3-propanediamine 【CA登记号】 |
【 分 子 式 】C14H19N3O 【 分 子 量 】245.32448 【元素组成】C 68.54% H 7.81% N 17.13% O 6.52% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VIII)Displacement of 2-chloro-4-ethoxyquinoline (VI) with 1,3-propanediamine (VII) affords the aminoquinoline (VIII). Subsequent acidic hydrolysis of (VIII) provides quinolinone (IX). Finally, reductive condensation between amine (IX) and ketone (V) in the presence of NaBH3CN leads to the target disubstituted propanediamine
| 【1】 Jarvest, R.L.; Berge, J.M.; Berry, V.; et al.; Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against Gram-positive pathogens. J Med Chem 2002, 45, 10, 1959. |
| 【2】 Berge, J.M.; Forrest, A.K.; Elder, J.S.; Jarvest, R.L. (GlaxoSmithKline plc); Quinolones as t-RNA synthetase inhibitors and antibacterial agents. WO 0021949 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (V) | 60626 | 6-ethyl-8-iodo-2,3-dihydro-4(1H)-quinolinone | C11H12INO | 详情 | 详情 | |
| (VI) | 60627 | 2-chloro-4-ethoxyquinoline; 2-chloro-4-quinolinyl ethyl ether | C11H10ClNO | 详情 | 详情 | |
| (VII) | 19331 | 3-aminopropylamine; 1,3-propanediamine | 109-76-2 | C3H10N2 | 详情 | 详情 |
| (VIII) | 60628 | N-(3-aminopropyl)-N-(4-ethoxy-2-quinolinyl)amine; N~1~-(4-ethoxy-2-quinolinyl)-1,3-propanediamine | C14H19N3O | 详情 | 详情 | |
| (IX) | 60629 | 2-[(3-aminopropyl)amino]-4(1H)-quinolinone | C12H15N3O | 详情 | 详情 |
Extended Information