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【结 构 式】 
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【分子编号】60624 【品名】3-(4-ethylanilino)propanoic acid 【CA登记号】 |
【 分 子 式 】C11H15NO2 【 分 子 量 】193.24564 【元素组成】C 68.37% H 7.82% N 7.25% O 16.56% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Condensation of 4-ethylaniline (I) with propiolactone (II) produces the beta-aminoacid (III). Intramolecular Friedel-Crafts cyclization of (III) by means of polyphosphoric acid leads to the quinolinone (IV). Then, electrophilic iodination of (IV) by using iodine monochloride provides the intermediate (V)
| 【1】 Jarvest, R.L.; Berge, J.M.; Berry, V.; et al.; Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against Gram-positive pathogens. J Med Chem 2002, 45, 10, 1959. |
| 【2】 Berge, J.M.; Forrest, A.K.; Elder, J.S.; Jarvest, R.L. (GlaxoSmithKline plc); Quinolones as t-RNA synthetase inhibitors and antibacterial agents. WO 0021949 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 60623 | 4-ethylaniline; 4-ethylphenylamine | C8H11N | 详情 | 详情 | |
| (II) | 24477 | 2-oxetanone | 57-57-8 | C3H4O2 | 详情 | 详情 |
| (III) | 60624 | 3-(4-ethylanilino)propanoic acid | C11H15NO2 | 详情 | 详情 | |
| (IV) | 60625 | 6-ethyl-2,3-dihydro-4(1H)-quinolinone | C11H13NO | 详情 | 详情 | |
| (V) | 60626 | 6-ethyl-8-iodo-2,3-dihydro-4(1H)-quinolinone | C11H12INO | 详情 | 详情 |
Extended Information