2-(1H-imidazol-5-yl)-1-ethanamine; 2-(1H-imidazol-5-yl)ethylamine -Drug Synthesis Database

【结构式】

【分子编号】60311

【品名】2-(1H-imidazol-5-yl)-1-ethanamine; 2-(1H-imidazol-5-yl)ethylamine

【CA登记号】

【分子式】C₅H₉N₃

【分子量】111.14668

【元素组成】C 54.03% H 8.16% N 37.81%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VI)

The title compound is prepared according to the Ugi reaction by combination of the four components: isocyanide (III), m-cyanobenzaldehyde (IV), 2-benzoylbenzoic acid (V), and histamine (VI) in refluxing MeOH

参考文献中间体

合成目标

【1】 Hirth, B.H.; Bernasconi, R.; Biemann, H.P.; et al.; Discovery of TNF-alpha induced apoptosis inhibitors with activity in a murine model of multiple sclerosis: Glycine diamides. 224th ACS Natl Meet (Aug 18 2002, Boston) 2002, Abst MEDI 272.
【2】 Hirth, B.H.; Sneddon, S.F.; Kane, J.L.; Vinick, F.; Qiao, S.; Nahill, S.R. (Genzyme Corp.); Modulators of TNF-alpha signaling. WO 0187849 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(III)	60310			C₁₅H₁₃N	详情	详情
(IV)	13245	3-Formylbenzonitrile; 3-Cyanobenzaldehyde	24964-64-5	C₈H₅NO	详情	详情
(V)	59365	2-benzophenone carboxylic acid; 2-Benzoylbenzoic acid; 2-Carboxybenzophenone; Benzophenone-2-carboxylic acid; O-benzoylbenzoic acid	85-52-9	C₁₄H₁₀O₃	详情	详情
(VI)	60311	2-(1H-imidazol-5-yl)-1-ethanamine; 2-(1H-imidazol-5-yl)ethylamine		C₅H₉N₃	详情	详情

Extended Information