8-bromo-2-methyl-4-quinolinol -Drug Synthesis Database

【结构式】

【分子编号】60306

【品名】8-bromo-2-methyl-4-quinolinol

【CA登记号】

【分子式】C₁₀H₈BrNO

【分子量】238.08366

【元素组成】C 50.45% H 3.39% Br 33.56% N 5.88% O 6.72%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

In a related synthetic strategy, 8-bromo-4-hydroxy-2-methylquinoline (I) is converted to aryl triflate (II) by using N-phenyl trifluoromethanesulfonimide and NaH. Displacement of the triflate group of (II) with 1,2,3,6-tetrahydropyridine-4-carboxamide (III) gives the tetrahydropyridyl quinoline (IV). The bromoquinoline (IV) is finally subjected to Suzuki coupling with 2,4-dichlorophenylboronic acid (V) to produce the title compound

参考文献中间体

合成目标

【1】 Kameo, K.; Kumagai, T.; Nakazato, A.; Okubo, T. (Taisho Pharmaceutical Co., Ltd.); Tetrahydropyridino or piperidino heterocyclic derivs.. EP 1299378; WO 0202549 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	60306	8-bromo-2-methyl-4-quinolinol		C₁₀H₈BrNO	详情	详情
(II)	60307	8-bromo-2-methyl-4-quinolinyl trifluoromethanesulfonate		C₁₁H₇BrF₃NO₃S	详情	详情
(III)	60299	1,2,3,6-tetrahydro-4-pyridinecarboxamide		C₆H₁₀N₂O	详情	详情
(IV)	60308	1-(8-bromo-2-methyl-4-quinolinyl)-1,2,3,6-tetrahydro-4-pyridinecarboxamide		C₁₆H₁₆BrN₃O	详情	详情
(V)	48912	2,4-Dichlorophenylboronic acid; 2,4-Dichlorobenzeneboronic acid	68716-47-2	C₆H₅BCl₂O₂	详情	详情

Extended Information