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【结 构 式】 
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【分子编号】60293 【品名】 【CA登记号】 |
【 分 子 式 】C16H18N2S 【 分 子 量 】270.3984 【元素组成】C 71.07% H 6.71% N 10.36% S 11.86% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IX)3,3-Diphenyl-1-propanol (VII) is converted into the corresponding alkyl bromide (VIII) by treatment with CBr4 and PPh3. Reaction of bromide (VIII) with thiourea provides the isothiouronium salt (IX), which is further hydrolyzed to thiol (X) under alkaline conditions. Finally, acylation of thiol (X) with carboxylic acid (VI) by means of DCC yields the target thioester
| 【1】 Hamilton, G.S.; Wu, Y.-Q.; Limburg, D.C.; Wilkinson, D.E.; Vaal ,M.J.; Li, J.-H.; Thomas, C.; Huang, W.; Sauer, H.; Ross, D.T.; Soni, R.; Chen, Y.; Guo, H.; Howorth, P.; Valentine, H.; Liang, S.; Spicer, D.; Fuller, M.; Steiner, J.P; Synthesis of N-glyoxyl prolyl and pipecolyl amides and thioesters and evaluation of their in vitro and in vivo nerve regenerative effects. J Med Chem 2002, 45, 16, 3549. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VI) | 60290 | 1-(3,3-dimethyl-2-oxopentanoyl)-2-piperidinecarboxylic acid | C13H21NO4 | 详情 | 详情 | |
| (VII) | 60291 | 3,3-diphenyl-1-propanol | C15H16O | 详情 | 详情 | |
| (VIII) | 60292 | 1-(3-bromo-1-phenylpropyl)benzene | C15H15Br | 详情 | 详情 | |
| (IX) | 60293 | C16H18N2S | 详情 | 详情 | ||
| (X) | 30783 | 3,3-diphenyl-1-propanethiol; 3,3-diphenylpropylhydrosulfide | C15H16S | 详情 | 详情 |
Extended Information