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【结 构 式】 
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【分子编号】60241 【品名】1-(2,4-dichlorophenyl)-2-(4-methyl-1H-imidazol-2-yl)-1-ethanone 【CA登记号】 |
【 分 子 式 】C12H10Cl2N2O 【 分 子 量 】269.12968 【元素组成】C 53.55% H 3.75% Cl 26.35% N 10.41% O 5.94% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Acylation of 2,4-dimethylimidazole (I) with 2,4-dichlorobenzoyl chloride (II) in the presence of diisopropylethylamine, followed by acidic hydrolysis, provides the 2-imidazolyl acetophenone (III). Subsequent condensation of (III) with dimethylformamide dimethylacetal gives rise to the enaminone (IV)
| 【1】 Brown, S.P.; Goff, D.; Ring, D.B.; Harrison, S.D.; Subramanian, S.; Nuss, J.M.; Boyce, R.S.; Johnson, K.; Pfister, K.B.; Ramurthy, S.; Renhowe, P.A.; Seely, L.; Wagman, A.S.; Zhou, X.A. (Chiron Corp.); Inhibitors of glycogen synthase kinase 3. EP 1087963; US 6417185; WO 9965897 . |
| 【2】 Ring, D.B.; Harrison, S.D.; Nuss, J.M.; Boyce, R.S.; Johnson, K.; Pfister, K.B.; Ramurthy, S.; Seely, L.; Wagman, A.S.; Desai, M.; Levine, B.H. (Chiron Corp.); Inhibitors of glycogen synthase kinase 3. WO 0220495 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 20613 | 2,4-dimethyl-1H-imidazole | 930-62-1 | C5H8N2 | 详情 | 详情 |
| (II) | 35131 | 2,4-dichlorobenzoyl chloride; 2,4-Dichlorophenacylchloride | 89-75-8 | C7H3Cl3O | 详情 | 详情 |
| (III) | 60241 | 1-(2,4-dichlorophenyl)-2-(4-methyl-1H-imidazol-2-yl)-1-ethanone | C12H10Cl2N2O | 详情 | 详情 | |
| (IV) | 60242 | 1-(2,4-dichlorophenyl)-3-(dimethylamino)-2-(4-methyl-1H-imidazol-2-yl)-2-propen-1-one | C15H15Cl2N3O | 详情 | 详情 |
Extended Information