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【结 构 式】

【分子编号】60217

【品名】{[2-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)propyl]oxy}methyl bis(1,1-dimethylethyl) phosphate

【CA登记号】

【 分 子 式 】C31H36F2N5O5PS

【 分 子 量 】659.6941084

【元素组成】C 56.44% H 5.5% F 5.76% N 10.62% O 12.13% P 4.7% S 4.86%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The condensation of BMS-207147 (I) with phosphoric acid di-tert-butyl chloromethyl triester (II) by means of NaH in THF gives the phosphoric triester (III), which is finally hydrolyzed with TFA in dichloromethane and treated with Na2CO3 to provide the target disodium salt.

1 Ueda, Y.; Barbour, N.; Bronson, J.J.; et al.; BMS-379224, a water-soluble prodrug of ravuconazole. 42nd Intersci Conf Antimicrob Agents Chemother (Sept 27 2002, San Diego) 2002, Abst F-817.
2 Hudyma, T.W.; Golik, J.; Ueda, Y.; Chen, C.-P.; Matiskella, J.D. (Bristol-Myers Squibb Co.); Water soluble prodrugs of azole cpds.. EP 1284737; US 6362172; WO 0152852 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 60212 4-{2-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-1,3-thiazol-4-yl}benzonitrile C22H17F2N5OS 详情 详情
(II) 42239 di(tert-butyl) chloromethyl phosphate;di-tert-butyl chloromethyl phosphate;PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER 229625-50-7 C9H20ClO4P 详情 详情
(III) 60217 {[2-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)propyl]oxy}methyl bis(1,1-dimethylethyl) phosphate C31H36F2N5O5PS 详情 详情
Extended Information