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【结 构 式】

【分子编号】60215

【品名】bis(1,1-dimethylethyl) hydrogen phosphate

【CA登记号】

【 分 子 式 】C8H19O4P

【 分 子 量 】210.210222

【元素组成】C 45.71% H 9.11% O 30.44% P 14.73%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

The condensation of BMS-207147 (I) with 3-(chloromethyl)benzoic acid chloromethyl ester (II) (obtained by esterification of 3-(chloromethyl)benzoyl chloride (III) with paraformaldehyde and ZnCl2) by means of KH in THF gives the adduct (IV), which is condensed with phosphoric acid di-tert-butyl ester (V) to yield the phosphate (V). Finally, this compound is hydrolyzed with TFA in dichloromethane and treated with NaHCO3 to provide the target sodium salt.

1 Hudyma, T.W.; Zheng, X.; Clark, J.; et al.; BMS-292655, a soluble prodrug of the clinically efficacious antifungal triazole, BMS-207147 (ravuconazole). 42nd Intersci Conf Antimicrob Agents Chemother (Sept 27 2002, San Diego) 2002, Abst F-816.
2 Hudyma, T.W.; Kim, O.K.; Zheng, X. (Bristol-Myers Squibb Co.); Water soluble prodrugs of azole cpds.. WO 0030655 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 60212 4-{2-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-1,3-thiazol-4-yl}benzonitrile C22H17F2N5OS 详情 详情
(II) 60213 chloromethyl 3-(chloromethyl)benzoate C9H8Cl2O2 详情 详情
(III) 25107 3-(chloromethyl)benzoyl chloride 63024-77-1 C8H6Cl2O 详情 详情
(IV) 20214 ethyl (3S)-3-benzyl-2-oxo-3-piperidinecarboxylate C15H19NO3 详情 详情
(V) 60215 bis(1,1-dimethylethyl) hydrogen phosphate C8H19O4P 详情 详情
(VI) 60216 {[2-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)propyl]oxy}methyl 3-[({bis[(1,1-dimethylethyl)oxy]phosphoryl}oxy)methyl]benzoate C39H42F2N5O7PS 详情 详情
Extended Information