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【结 构 式】 
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【分子编号】60162 【品名】4-fluorobenzonitrile 【CA登记号】 |
【 分 子 式 】C7H4FN 【 分 子 量 】121.1139032 【元素组成】C 69.42% H 3.33% F 15.69% N 11.56% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The reaction of 4-fluoroiodobenzene (I) with 14C-KCN and CuI in refluxing DMF gives 4-fluorobenzonitrile (II), which is reduced with HCO2H and RaNi in DMF to yield 4-fluorobenzaldehyde (III). The condensation of (III) with the substituted ethanolamine (IV) by means of tBu-OK in DMF affords 4-[2-[N-methyl-N-(2-pyridyl)amino]ethoxy]benzaldehyde (V), which is condensed with thiazolidine-2,4-dione (VI) by means of piperidine acetate in refluxing toluene to provide the benzylidene-thiazolidinedione (VII). Finally this compound is hydrogenated with H2 over Pd/C in DMF to furnish the target labeled compound.
| 【1】 Kirefu, T.; Landwater, S.W.; Latter, A.J.; Lawrie, K.W.M.; Morecombe, D.J.; Willcocks, K.; Rosiglitazone maleate (BRL 49653-C); the preparation of [14C] and [3H] isotopomers. J Label Compd Radiopharm 2001, 44, 5, 329. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 54686 | 1-Fluoro-4-iodobenzene; 4-Fluoroiodobenzene; 4-Iodofluorobenzene; p-Fluoroiodobenzene | 352-34-1 | C6H4FI | 详情 | 详情 |
| (II) | 60162 | 4-fluorobenzonitrile | C7H4FN | 详情 | 详情 | |
| (III) | 60163 | 4-fluorobenzaldehyde | C7H5FO | 详情 | 详情 | |
| (IV) | 17505 | 2-[methyl(2-pyridinyl)amino]-1-ethanol | C8H12N2O | 详情 | 详情 | |
| (V) | 60164 | 4-{2-[methyl(2-pyridinyl)amino]ethoxy}benzaldehyde | C15H16N2O2 | 详情 | 详情 | |
| (VI) | 10883 | 1,3-Thiazolane-2,4-dione; 2,4-Thiazolidinedione | 2295-31-0 | C3H3NO2S | 详情 | 详情 |
| (VII) | 59997 | C18H17N3O3S | 详情 | 详情 |
Extended Information