4-(4-chlorophenoxy)piperidine; 4-chlorophenyl 4-piperidinyl ether -Drug Synthesis Database

【结构式】

【分子编号】60099

【品名】4-(4-chlorophenoxy)piperidine; 4-chlorophenyl 4-piperidinyl ether

【CA登记号】

【分子式】C₁₁H₁₄ClNO

【分子量】211.691

【元素组成】C 62.41% H 6.67% Cl 16.75% N 6.62% O 7.56%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XIV)

Conversion of alcohol (XII) into alkyl bromide (XIII) is carried out by treatment with carbon tetrabromide and triphenylphosphine. Then condensation of bromide (XIII) with 4-(4-chlorophenoxy)piperidine (XIV) in the presence of NaI and NaHCO3 produces the title compound

参考文献中间体

合成目标

【1】 Forbes, I.T.; Douglas, S.; Gribble, A.D.; Ife, R.J.; Lightfoot, A.P.; Garner, A.E.; Riley, G.J.; Jeffery, P.; Stevens, A.J.; Stean, T.O.; Thomas, D.R.; SB-656104-A: A novel 5-HT(7) receptor antagonist with improved in vivo properties. Bioorg Med Chem Lett 2002, 12, 22, 3341.
【2】 Forbes, I.T.; Gribble, A.D. (GlaxoSmithKline plc); Sulfonamide cpds., their preparation and use. WO 0262788 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(XII)	60097	2-[(2R)-1-(1H-indol-6-ylsulfonyl)pyrrolidinyl]-1-ethanol	C₁₄H₁₈N₂O₃S	详情	详情
(XIII)	60098	6-{[(2R)-2-(2-bromoethyl)pyrrolidinyl]sulfonyl}-1H-indole	C₁₄H₁₇BrN₂O₂S	详情	详情
(XIV)	60099	4-(4-chlorophenoxy)piperidine; 4-chlorophenyl 4-piperidinyl ether	C₁₁H₁₄ClNO	详情	详情

Extended Information